Nanomaterials-Enhanced Electrochemical Biosensors for Epithelial Cancer Diagnosis: Recent Advances Regiart, Matías Giménez, Alba M. Ortega, Francisco G. Gómez, Germán E. Sáinz Pérez, Juan R. Tortella, Gonzalo Fernández-Baldo, Martín-A. Biosensor Electrochemical Nanomaterial In recent years, the interest in electrochemical biosensors has been constantly growing for epithelial cancer diagnosis and prognosis. The incorporation of the different nanomaterials as metal nanoparticles, magnetic nanoparticles, carbon nanomaterials, Metal–Organic Frameworks (MOFs), and nanocomposites, along with specific monoclonal antibodies, and nucleic acids (aptamers) has improved both sensitivity and specificity in these methodologies. In this review, we have presented examples of electrochemical biosensors for the determination of different epithelial cancer biomarkers. Based on numerous reports in the recent literature, we highlight the use of single and multiplexed analytical platforms for the quantification of epithelial cancer biomarkers. In addition, we outline potential development pathways, current challenges, and future prospects in the field of electrochemical immuno-, apta-, and genosensors. 2025-11-24T08:23:45Z 2025-11-24T08:23:45Z 2025-11-22 journal article Regiart, M.; Gimenez, A.M.; Ortega, F.G.; Gómez, G.E.; Sainz, J.; Tortella, G.R.; Fernández-Baldo, M.A. Nanomaterials-Enhanced Electrochemical Biosensors for Epithelial Cancer Diagnosis: Recent Advances. Biosensors 2025, 15, 766. https://doi.org/10.3390/bios15120766 https://hdl.handle.net/10481/108232 10.3390/bios15120766 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI