High-Resolution Mass Spectrometry to advance DBP research Zuo, Xin Changchun, Xin Postigo, Cristina high-molecular weight DBPs Non-target screening Polar organic compounds In recent years, HRMS has been widely applied in the field of water disinfection and DBP research. Its use has enabled not only DBP discovery but also the identification of DBP precursors and the elucidation of DBP formation mechanisms and toxicity modes of action. The present manuscript overviews the most recent (mainly from 2023 to present) HRMS-based applications, and discusses main innovations, limitations, challenges, and knowledge gaps to inspire future research in the field. 2025-11-14T12:37:48Z 2025-11-14T12:37:48Z 2025-10-13 journal article Zuo X, Xin C, Postigo C, High-Resolution Mass Spectrometry to advance DBP research, Current Opinion in Environmental Science & Health, https://doi.org/10.1016/ j.coesh.2025.100682 https://hdl.handle.net/10481/108005 10.1016/j.coesh.2025.100682 eng info:eu-repo/grantAgreement/EU/PRTR/CNS2023-145248 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elservier