Transcriptomics and epigenomics datasets of primary brain cancers in formalin-fixed paraffin embedded format García Heredia, Anabel Guerra-Núñez, Luna Martín-Climent, Paula Rojas, Estefanía López-Domínguez, Raúl Alcántara Domínguez, Clara Alenda, Cristina Valor, Luis M. The access of public omics-based datasets is of paramount importance in brain cancer research as allows the proposal and validation of both biomarkers and therapeutic targets in gliomas, especially in the most prevalent and aggressive glioblastomas. Taking profit of current advances in next generation sequencing and DNA methylation profiling, we have created datasets from approximately 150 formalin-fixed paraffin embedded (FFPE) tumours. These datasets enable for the first time integrative transcriptional and epigenetics studies in a context that consider the degradation and fixation-derived chemical alterations of the most extended archiving format in hospitals, and provide an independent cohort from current public databases for further validation of putative novel biomarkers. Alongside with the most profusely known glioblastomas, astrocytomas and oligodendrogliomas, we have also included for comparison purposes few examples of rare tumours that are often neglected in brain cancer research. Taken together, we provide a valuable tool to explore combined gene expression and DNA methylation patterns in the study of gliomas and glioneuronal tumours. 2025-11-14T09:09:25Z 2025-11-14T09:09:25Z 2025-02-15 journal article García-Heredia, A., Guerra-Núñez, L., Martín-Climent, P. et al. Transcriptomics and epigenomics datasets of primary brain cancers in formalin-fixed paraffin embedded format. Sci Data 12, 273 (2025). https://doi.org/10.1038/s41597-025-04597-6 https://hdl.handle.net/10481/107986 10.1038/s41597-025-04597-6 eng info:eu-repo/grantAgreement/EU/PRTR/INVEST/2022/447 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer Nature