Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity López Melero, María Elena Nigrón, E. Haddad, F. Praena Rodríguez, Antonio Javier 177Lu 117mLu Cross-sections Activation cross-sections of lutetium and ytterbium radionuclides have been measured by deuteron-induced nuclear reaction on natYb(d,x) at the GIP ARRONAX (Saint-Herblain, France) cyclotron facility with a beam energy up to 33 MeV using the stacked-foil activation technique combined with high resolution γ-ray spectrometry. The measured experimental values enable the extension of the cross-section to higher energies. As a primary objective, we have focused on the cumulative measurement of the direct and indirect production routes of the therapeutic radioisotope 177gLu, via 176Yb(d,n) 177 g,mLu and 176Yb(d,p) 177Yb → 177gLu respectively. Post-irradiation gamma analysis, including a long gamma counting period, was performed to calculate the yield of the undesirable metastable isotopic impurity 177mLu. The results showed that it was found to be lower than our detection limit i.e. <0.0005% of 177gLu yield. Thick target yields for all detected radionuclides are also calculated in this paper. These measurements enabled the estimation of the production yield and isotopic purity of 177Lu obtained via deuteron-induced nuclear reactions for large production batches using highly enriched 176Yb2O3 samples (>99.5%). 2025-11-10T10:37:53Z 2025-11-10T10:37:53Z 2026-01 journal article López-Melero, E., Nigron, E., Haddad, F., & Praena, J. (2025). Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity. Applied Radiation and Isotopes: Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine, 227(112263), 112263. https://doi.org/10.1016/j.apradiso.2025.112263 https://hdl.handle.net/10481/107885 10.1016/j.apradiso.2025.112263 eng info:eu-repo/grantAgreement/EU/HE/101052200 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Elsevier