3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides Carretero Coca, Rafael AHR Cancer Small mollecule inhibitor The present invention covers 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine- 4-carboxamide compounds of general formula (I): in which R1, R2, R4, R5, R6, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients. 2025-11-06T12:31:44Z 2025-11-06T12:31:44Z 2019-05-31 patent WO2019101643A1: 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides WO2019101643A1 https://hdl.handle.net/10481/107812 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional WIPO/PCT