Enhancement of the Chiroptical Properties of o‑OPE through Arene−Perfluoroarene Interactions Otero, Darío Martínez Pinel, Álvaro Ortuño Guzmán, Ana María Álvarez de Cienfuegos, Luis Cuerva Carvajal, Juan Manuel Longhi, Giovanna Millán Delgado, Alba Miguel Álvarez, Delia In this work, we synthesized and studied fluorinated o-oligophenylene ethynylenes (o-OPEs). Arene−perfluoroarene interactions promote the folding of the extremes of the OPE stabilizing folded conformations and extending the helical conformation to two complete turns, thus improving their chiroptical responses compared to the nonfluorinated analogue. Dissymmetry factors gabs and glum reached values of ∼3 × 10−2 on the perfluorinated compound, which represents a 3-fold increase compared to that of the nonfluorinated analogue and is an exceptional value for a small organic molecule. 2025-11-04T11:22:25Z 2025-11-04T11:22:25Z 2025-07-30 journal article Otero, D., Martínez-Pinel, Á., Ortuño, A. M., Álvarez de Cienfuegos, L., Cuerva, J. M., Longhi, G., Millán, A., & Miguel, D. (2025). Enhancement of the chiroptical properties of o-OPE through Arene-perfluoroarene interactions. Organic Letters, 27(31), 8459–8463. https://doi.org/10.1021/acs.orglett.5c02277 https://hdl.handle.net/10481/107749 10.1021/acs.orglett.5c02277 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional American Chemical Society