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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/107604">
      <dc:title>O-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity</dc:title>
      <dc:creator>Corpas-López, Victoriano</dc:creator>
      <dc:creator>Tabraue-Chavez, Mavys</dc:creator>
      <dc:creator>Sixto-López, Yudibeth</dc:creator>
      <dc:creator>Panadero-Fajardo, Sonia</dc:creator>
      <dc:creator>Alves de Lima Franco, Fernando</dc:creator>
      <dc:creator>Domínguez Seglar, José Francisco</dc:creator>
      <dc:creator>Morillas Márquez, Francisco</dc:creator>
      <dc:creator>Franco Montalbán, Francisco</dc:creator>
      <dc:creator>Díaz Gavilán, Mónica</dc:creator>
      <dc:creator>Correa-Basurto, José</dc:creator>
      <dc:creator>López-Viota, Julián</dc:creator>
      <dc:creator>López-Viota Gallardo, Margarita</dc:creator>
      <dc:creator>Pérez del Palacio, José</dc:creator>
      <dc:creator>de la Cruz, Mercedes</dc:creator>
      <dc:creator>de Pedro, Nuria</dc:creator>
      <dc:creator>Martín Sánchez, Joaquina</dc:creator>
      <dc:creator>Gómez Vidal, José Antonio</dc:creator>
      <dc:subject>Metal nanoparticles</dc:subject>
      <dc:subject>Nanoparticles</dc:subject>
      <dc:subject>Parasites</dc:subject>
      <dc:subject>Peptides and proteins</dc:subject>
      <dc:subject>Redox reactions</dc:subject>
      <dc:description>Versión del autor (manuscrito aceptado) depositada conforme a la política de autoarchivo de la editorial American Chemical Society (ACS Publications) para el Journal of Medicinal Chemistry (ver: https://openpolicyfinder.jisc.ac.uk/id/publication/7786&#xd;
).&#xd;
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De acuerdo con dicha política, el autor puede depositar en repositorios institucionales la versión aceptada del manuscrito tras un embargo de 12 meses desde la publicación. Dado que el artículo fue publicado en 2020, el periodo de embargo ha finalizado y esta versión puede difundirse en acceso abierto.</dc:description>
      <dc:description>Leishmania (L.) infantum causes visceral, cutaneous, and mucosal leishmaniasis in humans and canine leishmaniasis in dogs. Herein, we describe that O-alkyl hydroxamate derivatives displayed potent and selective in vitro activity against the amastigote stage of L. infantum while no activity was observed against promastigotes. Compound 5 showed potent in vivo activity against L. infantum. Moreover, the combination of compound 5 supported on gold nanoparticles and meglumine antimoniate was also effective in vivo and improved the activity of these compounds compared to that of the individual treatment. Docking studies showed that compound 5 did not reach highly conserved pocket C and established interactions with the semiconserved residues V44, A45, R242, and E243 in pocket A of LiSIR2rp1. The surface space determined by these four amino acids is not conserved in human sirtuins. Compound 5 represents a new class of selective ligands with antileishmanial activity.</dc:description>
      <dc:date>2025-10-30T12:06:59Z</dc:date>
      <dc:date>2025-10-30T12:06:59Z</dc:date>
      <dc:date>2020-06-11</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>https://hdl.handle.net/10481/107604</dc:identifier>
      <dc:identifier>https://doi.org/10.1021/acs.jmedchem.9b02016</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>open access</dc:rights>
      <dc:publisher>American Chemical Society</dc:publisher>
   </ow:Publication>
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