Reactive ZIF-L Crystal Surface for Organophosphorous Degradation and Acetylcholinesterase Reactivation Borrego Marin, Emilio Garrido-Barros, Pablo Peterson, Gregory W. Vismara, Rebecca Carmona Fernández, Francisco Jesús Barea Martínez, Elisa María Rodríguez Navarro, Jorge Andrés Crystals Degradation Exfoliation Proteins Reactivity The authors are grateful to Spanish MCIN/AEI/10.13039/501100011033 (Projects PID2023-147972OB-I00) and “ERDF-EU”. E.B.-M. acknowledges the Spanish Ministry of Education for a predoctoral fellowship (FPU23/01844). P.G.-B. is thankful for the grant RYC2021-031249-I funded by MICIU/AEI/10.13039/501100011033 and by “European Union NextGenerationEU/PRTR”. The importance of crystal surface reactivity of reticular materials is exemplified by exfoliation of nonporous layered zeolitic imidazolate framework Zn(mIm)2·0.5mImH (ZIF-L, mImH = 2-methylimidazole). Sonication of ZIF-L ethanolic suspensions leads to exfoliation of microcrystals along the 2 0 0 planes, giving rise to 1.5 μm wide × 25 nm thick flakes, which we term ZIF-L_exf. ZIF-L_exf exhibits a high reactivity toward hydrolytic degradation of extremely toxic G-type nerve agents, Soman (GD), and simulant diisopropylfluorophosphate (DIFP). The reactivity of the crystal surface of ZIF-L_exf toward P–F bond breakdown gives rise to framework structural degradation, releasing nucleophilic mImH molecules that reactivate organophosphate-inhibited acetylcholinesterase within 10 min. This detoxification process can be taken as a proof of concept for reversing organophosphorous poisoning. More generally, this approach underscores the importance of the crystal surface nature and composition to control the reactivity of reticular materials. 2025-10-29T10:48:14Z 2025-10-29T10:48:14Z 2025-03-11 journal article Published version: Emilio Borrego-Marin et al. J. Am. Chem. Soc. 2025, 147, 13, 10834–10839. doi:10.1021/jacs.5c00382 https://hdl.handle.net/10481/107563 10.1021/jacs.5c00382 eng open access American Chemical Society