Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism—Association with prostate cancer Álvarez-González, Beatriz Hernández Jérez, Antonio Francisco Zafra Gómez, Alberto Chica-Redecillas, Lucía Cuenca-López, Sergio Vázquez-Alonso, Fernando Martínez González, Luis Javier Álvarez Cubero, María Jesús Genetic Polymorphisms Prostate cancer Environmental exposure Biomonitoring Organic Pollutans This study assessed whether genetic variants coding for certain enzymes involved in xenobiotic detoxification, antioxidant defences and DNA repair, along with exposure to environmental chemicals, were associated with an increased prostate cancer (PCa) risk. The study population consisted of 300 men (150 PCa cases and 150 controls) which underwent prostate biopsy as their serum prostate specific antigen (PSA) levels were greater than 4 ng/ml. Genetic variants in GSTM1, GSTP1, SOD2, CAT, GPX1, XRCC1 were determined and data for chemical exposures was obtained through a structured questionnaire and by biomonitoring in a subsample of cases and controls. High serum PSA levels were associated with a greater risk of PCa, while physical exercise appears to exert a protective effect against its development. In addition, elevated urinary levels of certain organic pollutants, such as benzo(a)pyrene (BaP), bisphenol A (BPA), and ethyl-paraben (EPB), were associated with an increased risk of PCa. 2025-10-28T09:14:02Z 2025-10-28T09:14:02Z 2024 journal article Environmental Toxicology and Pharmacology 108 (2024) 104455 https://hdl.handle.net/10481/107520 https://doi.org/10.1016/j.etap.2024.104455 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Attribution-NonCommercial-NoDerivatives 4.0 Internacional Elsevier