<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/107216">
      <dc:title>Personality traits associated with tinnitus: A systematic review and contributing genetic variants</dc:title>
      <dc:creator>Bernardez-Robledano, Alberto</dc:creator>
      <dc:creator>Parra Pérez, Alberto Manuel</dc:creator>
      <dc:creator>Moleon, María del Carmen</dc:creator>
      <dc:creator>Lopez-Escamez, Jose Antonio</dc:creator>
      <dc:creator>Pérez-Carpena, Patricia</dc:creator>
      <dc:subject>Tinnitus</dc:subject>
      <dc:subject>Personality traits</dc:subject>
      <dc:subject>Neuroticism</dc:subject>
      <dc:description>Chronic tinnitus is multifaceted condition associated with auditory (hearing loss, hyperacusis), neurological&#xd;
(headache) and psychological disorders (anxiety, depression). Personality traits may determine how tinnitus is&#xd;
perceived, and common genetic variation contributes to shape personality. The goal of this systematic review is&#xd;
to analyze evidence supporting a link between personality traits and tinnitus. Published articles about tinnitus&#xd;
and personality related to the Big Five Traits were included. Based on 7 studies, this systematic review identified&#xd;
the neuroticism trait as the main potential connection between personality and tinnitus suffering. The consistency of this relationship is evident across different Big Five personality tools, with similar outcomes observed&#xd;
regardless of the instrument used, reinforcing the consistency of this association. In order to establish a genetics&#xd;
association, a GWAS based search revealed common genetic variants in the GRM5, XKR6, GRM8, TCF4, and&#xd;
SLC39A8 genes, with SLC39A8 identified as a shared missense variant rs13107325 (C/T, p.Ala391Thr) between&#xd;
neuroticism and tinnitus. The role of these genes in important neural functions points to possible shared&#xd;
mechanisms underlying both conditions.</dc:description>
      <dc:date>2025-10-21T08:45:50Z</dc:date>
      <dc:date>2025-10-21T08:45:50Z</dc:date>
      <dc:date>2025-11</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Bernal-Robledano, A., Parra-Perez, A. M., Moleon, M. D. C., Lopez-Escámez, J. A., &amp; Perez-Carpena, P. (2025). Personality traits associated with tinnitus: A systematic review and contributing genetic variants. Neuroscience and Biobehavioral Reviews, 178(106389), 106389. https://doi.org/10.1016/j.neubiorev.2025.106389</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/107216</dc:identifier>
      <dc:identifier>10.1016/j.neubiorev.2025.106389</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 Internacional</dc:rights>
      <dc:publisher>Elsevier</dc:publisher>
   </ow:Publication>
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