<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/106952">
      <dc:title>Reduced Systemic Levels of Bile Acids in Individuals with Coronary Artery Disease: Insights from a Systematic Review</dc:title>
      <dc:creator>López Espinosa, Víctor Manuel</dc:creator>
      <dc:creator>Amaro-Gahete, Francisco J.</dc:creator>
      <dc:creator>Osuna-Prieto, Francisco J.</dc:creator>
      <dc:subject>Atherosclerosis</dc:subject>
      <dc:subject>Lipid metabolism</dc:subject>
      <dc:subject>Cardiovascular Risk</dc:subject>
      <dc:description>Bile acids (BAs) play a key role in cholesterol metabolism and inflammation. Although&#xd;
altered circulating BA profiles have been reported in cardiometabolic disorders such as&#xd;
type 2 diabetes (T2D) and obesity, their relationship with coronary artery disease (CAD)&#xd;
remains poorly understood. We conducted a systematic review of human studies searching&#xd;
PubMed, Web of Science, and Scopus, assessing circulating BA concentrations in adults with&#xd;
angiographically confirmed CAD compared to non-CAD (NCAD) controls. Risk of bias&#xd;
was evaluated using the Newcastle–Ottawa Scale. From 2782 records, four observational&#xd;
studies met the inclusion criteria. All reported lower circulating BA concentrations in&#xd;
individuals with CAD compared to NCAD controls, with differences ranging from −5.4%&#xd;
to −52.8%. Two studies found a significant inverse association between BA levels and CAD.&#xd;
One study reported lower BA levels only in CAD in men, while another found the reduction&#xd;
more pronounced in individuals with T2D. However, all studies were observational, and&#xd;
most lacked adjustment for confounders such as sex and age. Current evidence suggests&#xd;
that lower circulating BA levels are linked to CAD and may be influenced by sex and T2D&#xd;
status. Further mechanistic and prospective studies are needed to clarify the relevance and&#xd;
directionality of this association.</dc:description>
      <dc:date>2025-10-10T10:02:44Z</dc:date>
      <dc:date>2025-10-10T10:02:44Z</dc:date>
      <dc:date>2025-09-09</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>López Espinosa, V.M.; Amaro-Gahete, F.J.; Osuna-Prieto, F.J. Reduced Systemic Levels of Bile Acids in Individuals with Coronary Artery Disease: Insights from a Systematic Review. Int. J. Mol. Sci. 2025, 26, 8764. https://doi.org/10.3390/ijms26188764</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/106952</dc:identifier>
      <dc:identifier>10.3390/ijms26188764</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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