<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/106922">
      <dc:title>Global copper response of the soil bacterial predator Myxococcus xanthus and its contribution to antibiotic cross-resistance</dc:title>
      <dc:creator>Marcos Torres, Francisco Javier</dc:creator>
      <dc:creator>Pérez Torres, Juana</dc:creator>
      <dc:creator>Torrens González, David</dc:creator>
      <dc:creator>García Pedrosa, Miguel Ángel</dc:creator>
      <dc:creator>Contreras Moreno, Francisco Javier</dc:creator>
      <dc:creator>Moraleda Muñoz, Aurelio</dc:creator>
      <dc:subject>Copper homeostasis</dc:subject>
      <dc:subject>Antibiotic co-resistance</dc:subject>
      <dc:subject>Bacterial predation</dc:subject>
      <dc:subject>Myxococcus xanthus</dc:subject>
      <dc:subject>Sinorhizobium meliloti</dc:subject>
      <dc:description>Copper accumulation in agricultural soils poses environmental challenges by selecting copper-resistant bacteria and also contributing to the co-selection of antibiotic-resistant bacteria. In addition, copper influences bacterial predator-prey interactions, potentially altering microbial ecosystems. Myxococcus xanthus, a soil-dwelling bacterium, preys on other microorganisms, including Sinorhizobium meliloti, a symbiotic nitrogen-fixing bacterium associated with leguminous plants. The role of copper in M. xanthus interactions remains poorly understood, although it accumulates at the predator-prey interface. In this study, we explore the transcriptomic response of M. xanthus to copper stress in both monocultures and co-cultures with S. meliloti. Our analysis identified many myxobacterial copper-regulated transcripts, and studies on mutant strains in some copper-induced genes revealed the role of two efflux pumps in cross-resistance to copper and tetracyclines. These findings provide new insights into the adaptive mechanisms of M. xanthus in response to copper, with implications for the co-selection of antibiotic resistance and the broader impact of copper on microbial community dynamics in soil ecosystems.</dc:description>
      <dc:date>2025-10-09T12:19:25Z</dc:date>
      <dc:date>2025-10-09T12:19:25Z</dc:date>
      <dc:date>2025-10-01</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Marcos-Torres FJ, Pérez J, Torrens-González D, García-Pedrosa MÁ, Contreras-Moreno FJ, Moraleda-Muñoz A. Global copper response of the soil bacterial predator Myxococcus xanthus and its contribution to antibiotic cross-resistance. Microbiol Res. 2025 Oct 1;302:128357. doi: 10.1016/j.micres.2025.128357</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/106922</dc:identifier>
      <dc:identifier>10.1016/j.micres.2025.128357</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución-NoComercial 4.0 Internacional</dc:rights>
      <dc:publisher>Elsevier</dc:publisher>
   </ow:Publication>
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