Young Smokers’ Therapy Preferences: App-Based vs. Face-to-Face Treatment in the Context of Co-Addictions López-Torrecillas, Francisca Arcos-Rueda, María del Mar Cobo-Rodríguez, Beatriz Muñoz-López, Lucas Smoking cessation app-based therapy face-to-face therapy Background: Tobacco use remains a major public health concern among young adults and is often complicated by co-occurring addictive behaviors. Objective: This study analyzed motivation for change, assessed with the decisional balance framework, in relation to multiple addictions among young smokers seeking treatment. Methods: Ninety-eight participants from the University of Granada enrolled in either an app-based cognitive– behavioral therapy (CBT) program (n = 35) or a traditional face-to-face CBT program (n = 63). Recruitment relied on self-identification and voluntary participation. Standardized instruments were applied to measure nicotine dependence (FTND), behavioral and substance-related addictions (MULTICAGE CAD-4), cannabis dependence (SDS), and motivation for change (DBQ). Logistic and stepwise regression analyses were conducted to identify predictors of treatment choice and motivational outcomes. Results: Younger participants and students were more likely to choose the app-based program. Compulsive buying was linked to perceiving more disadvantages of smoking, whereas sex addiction, cannabis dependence, and other substance addictions were associated with perceiving fewer disadvantages. Conclusions: Treatment preferences and motivational profiles differ according to age, academic status, and co-occurring addictions. These findings highlight the need to tailor smoking cessation strategies to individual profiles and support the role of mobile health tools in engaging digitally oriented populations. 2025-09-23T11:24:27Z 2025-09-23T11:24:27Z 2025-09-17 journal article López-Torrecillas, F.; Arcos-Rueda, M.d.M.; CoboRodríguez, B.; Muñoz-López, L. Young Smokers’ Therapy Preferences: App-Based vs. Face-to-Face Treatment in the Context of Co-Addictions. Healthcare 2025, 13, 2326. https://doi.org/10.3390/healthcare13182326 https://hdl.handle.net/10481/106562 10.3390/healthcare13182326 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI