Microbiological Relevance of Candida in Urine Cultures Castellano-Sánchez, Leticia Rosales-Castillo, Antonio Marcos-Rodríguez, Raquel Olvera-Porcel, Maria Carmen Navarro-Marí, José María Gutierrez-Fernandez, Jose Candida Urine Hospitalization Intensive care Urinary catheter Urine culture The presence of Candida spp. in urine has traditionally been considered to be a colonization; however, in certain clinical circumstances, such as in critically ill patients, immunocompromised individuals, or those with chronic diseases, it gains greater relevance due to the possibility of active infection and complications. The aim of this study was to characterize the epidemiology (incidence, species distribution, demographic characteristics, and origin) of Candida spp. isolates in urine through a retrospective cross-sectional analysis of urine culture isolates from clinical samples between January 2016 and December 2023. Out of a total of 111,656 urine cultures, Candida spp. was isolated at 2.72% (n = 3037). The most frequently isolated species was Candida albicans (54.25%; 1646/3037), followed by Nakaseomyces glabrata (22.78%; 692/3037) and Candida tropicalis (10.2%; 311/3037). Advanced age (>70 years), male sex, presence of a urinary catheter, and origin from intensive care units, oncology, or surgical services were variables associated with a higher risk of candiduria, highlighting the relevance of candiduria in the presence of such clinical scenarios. 2025-09-05T09:04:33Z 2025-09-05T09:04:33Z 2025-06-26 journal article Castellano-Sánchez, L.; Rosales-Castillo, A.; Marcos-Rodríguez, R.; Olvera-Porcel, M.C.; Navarro-Marí, J.M.; Gutiérrez-Fernández, J. Microbiological Relevance of Candida in Urine Cultures. J. Fungi 2025, 11, 483. https://doi.org/10.3390/jof11070483 https://hdl.handle.net/10481/106088 10.3390/jof11070483 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI