Intraocular pressure and ocular perfusion pressure responses during low-intensity endurance exercise in primary-open angle glaucoma patients versus age- and sex-matched controls: Influence of walking pace and external load Morenas Aguilar, María Dolores González‑Hernández, Cristina Chacon Ventura, Sara Ortiz Pérez, Santiago Ramos López, Juan Francisco García Ramos, Amador Vera, Jesús Endurance training Glaucoma Physical activity POAG patients This study compared the effects of low-intensity endurance exercise at two different walking paces with/without external loads on intraocular pressure (IOP) and ocular perfusion pressure (OPP) in primary open-angle glaucoma patients (POAG) and matched controls. Twenty-one POAG patients and 17 healthy individuals performed four 400-m walking protocols (slow/fast × with/without loads). IOP was measured before exercise, during the walking test and after 1 and 5 min of recovery. OPP was assessed before exercise and after 1 and 5 min of recovery. IOP was stable in POAG patients during the execution of low-intensity endurance exercise (p = 0.14) regardless of the walking pace and the use of external loads (both p > 0.69). However, controls showed a moderate IOP rise during the walking test (p < 0.001), with this effect being heightened when using external loads (p < 0.001). Both groups experienced a transient OPP rise after exercise (p < 0.001) and this increase was greater in the fast- than the slow-paced condition (p = 0.049). POAG patients showed stable IOP while walking at slow and fast speeds, while OPP increased after walking, particularly at a fast pace. These findings suggest that low-intensity endurance exercise is a safe strategy to improve fitness levels in POAG patients. 2025-07-30T07:18:23Z 2025-07-30T07:18:23Z 2025-05-30 journal article Morenas-Aguilar, M. D., Hernández, C. G., Chacón-Ventura, S., Ortiz-Perez, S., Ramos-López, J. F., García-Ramos, A., & Vera, J. (2025). Intraocular pressure and ocular perfusion pressure responses during low-intensity endurance exercise in primary-open angle glaucoma patients versus age- and sex-matched controls: Influence of walking pace and external load. Ophthalmic & Physiological Optics: The Journal of the British College of Ophthalmic Opticians (Optometrists). https://doi.org/10.1111/opo.13531 https://hdl.handle.net/10481/105830 10.1111/opo.13531 eng http://creativecommons.org/licenses/by-nc/4.0/ open access Atribución-NoComercial 4.0 Internacional John Wiley & Sons, Ltd.