Effectiveness of Titanium Occlusive Barriers in Guided Bone Regeneration: A Prospective Analysis of Vertical and Horizontal Bone Augmentation Leiva-Gea, Luis Sánchez-Palomino, Paulino Lendínez-Jurado, Alfonso Corte-Torres, María Daniela Leiva-Gea, Isabel Leiva-Gea, Antonio Guided bone regeneration Titanium barriers Bone augmentation Dental implants Background: Guided bone regeneration (GBR) is a widely used technique in oral and maxillofacial surgery to restore lost bone. The aim of this study is to evaluate the effectiveness of titanium occlusive barriers in GBR for increasing bone volume in both vertical and horizontal dimensions. Methods: A prospective analysis was conducted on 11 patients (15 cases) undergoing bone augmentation with titanium barriers combined with bone graft biomaterials for dental implant placement. Bone gain was assessed using pre- and postoperative low-dose cone beam computed tomography (CBCT) measurements in vertical and horizontal planes. Histological analyses evaluated the quality and vascularization of the regenerated bone. Results: Significant bone volume increases were observed, with a mean vertical gain of 7.60 mm (SD 0.23) and a horizontal gain of 5.44 mm (SD 0.39). Histological examination confirmed well-vascularized regenerated bone with minimal residual graft material, effective integration, and the formation of keratinized gingiva. Conclusions: Titanium occlusive barriers in GBR provide a reliable and minimally invasive method for substantial bone regeneration, showing advantages such as ease of handling and reduced invasiveness. Additional studies are recommended to validate these findings and evaluate long-term outcomes 2025-07-28T09:49:59Z 2025-07-28T09:49:59Z 2025-03-07 journal article Leiva-Gea, L.; SánchezPalomino, P.; Lendínez-Jurado, A.; Corte-Torres, M.D.; Leiva-Gea, I.; Leiva-Gea, A. Effectiveness of Titanium Occlusive Barriers in Guided Bone Regeneration: A Prospective Analysis of Vertical and Horizontal Bone Augmentation. Biomimetics 2025, 10, 165. https://doi.org/10.3390/ biomimetics10030165 https://hdl.handle.net/10481/105756 10.3390/ biomimetics10030165 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI