Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: A longitudinal study Frejo, Lidia Cara, Francisca E. Flook, Marisa Robles Bolívar, Paula Escalera Balsera, Alba Montilla Ibáñez, María Alharilla Dominguez Durán, Emilio Martínez Martínez, Marta Pérez Carpena, Patricia López Escámez, José Antonio Cytokines Inflammation IL-1β IgE Meniere disease Background: Meniere disease (MD), an inner ear disorder influenced by genetic and environmental factors, potentially leads to chronic inflammation. This study evaluates whether inflammation in MD patients is driven by allergy or autoinflammation. Methods: 2-year longitudinal study. Cytokine and chemokine levels were measured in plasma from 72 patients. Functional clusters were identified using weighted-based discriminant and km3d trajectory analyses. THP-1 cells were exposed to patients' plasma to assess macrophage polarization, and qPCR analyzed upstream cytokine release events. Results: Four groups were identified: 1) Autoimmune (20 %) with high TNF-α (p = 0.0004); 2) Allergic (25 %) with elevated IgE (p < 0.0001) and M2 polarization; 3) Autoinflammatory (13 %) with increased IL-1β (p < 0.0001), activated via CASP1/NLRP3; 4) Low cytokine levels (42 %; cytokines in Q1). Group stability was observed, with 36 % of allergic patients also showing high IL-1β. Conclusion: Identified immunophenotypes, allergy-driven IgE responses, and IL-1β-mediated autoinflammation indicate that targeting inflammation with biomarkers could optimize MD treatment and outcomes. 2025-07-17T07:43:35Z 2025-07-17T07:43:35Z 2024-11-30 journal article Frejo, L., Cara, F. E., Flook, M., Robles-Bolivar, P., Escalera-Balsera, A., Montilla-Ibañez, M. A., Dominguez-Duran, E., Martinez-Martinez, M., Perez-Carpena, P., & Lopez-Escamez, J. A. (2025). Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: A longitudinal study. Clinical Immunology (Orlando, Fla.), 271(110413), 110413. https://doi.org/10.1016/j.clim.2024.110413 https://hdl.handle.net/10481/105394 10.1016/j.clim.2024.110413 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Elsevier