Impact of surgery on rehabilitation care and quality of life perceived by patient with post-stroke upper limb spasticity: Study protocol for a randomized controlled trial Hurtado Olmo, Patricia Gonzalez-Santos, Ángela del Olmo Iruela, Laura Castro-Ropero, Belén Zúñiga Gómez, Lourdes Bueno-García, Ana Isabel Guijosa-Campos, Pilar Gómez-Pozo, Basilio Hita Contreras, Fidel Hernández Cortés, Pedro Manuel Stroke is the principal cause of permanent disability in adult age, and many patients require lifelong medical treatment and care from others for their daily activities. It has enormous repercussions on the work and social lives of patients and their families and involves major economic expenditure. Post-stroke spastic upper limb is usually treated with rehabilitation, occupational therapy, and periodical injections of botulinum toxin, while surgical correction is now seldom considered. However, there has been no clinical trial to compare between surgical and toxin treatments. The primary aim of this study is to compare outcomes between surgery and a conventional approach with botulinum toxin in patients with post-stroke upper limb spasticity. 2025-07-09T07:19:59Z 2025-07-09T07:19:59Z 2025-04-30 journal article Hurtado-Olmo P, González-Santos Á, del Olmo Iruela L, Castro-Ropero B, ZúñigaGómez L, Bueno-García AI, et al. (2025) Impact of surgery on rehabilitation care and quality of life perceived by patient with post-stroke upper limb spasticity: Study protocol for a randomized controlled trial. PLoS One 20(4): e0322588. [DOI. 10.1371/journal.pone.0322588] https://hdl.handle.net/10481/105132 10.1371/journal.pone.0322588 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Plos One