Prevalence and Predictors of Work–Life Balance Among Nursing Personnel During the Sixth Wave of the Pandemic: The Role of Stress and Sociodemographic and Work-Related Variables Antolí Jover, Ana María Gázquez López, María Brieba del Río, Pascual Martín Salvador, Adelina Martínez García, Encarnación Sánchez García, Inmaculada Álvarez Serrano, María Adelaida work–life conflict family support occupational stress nursing health personnel COVID-19 The COVID-19 pandemic has intensified the challenges of balancing work and personal life for healthcare professionals, particularly nurses. In Spain, during the sixth wave of the pandemic, characterized by a high number of infections and increased health- care pressure, these challenges became even more pronounced. This study examines how perceived stress, sociodemographic characteristics, and work-related factors influence Work–Life Balance among Spanish nurses in this context. A cross-sectional study was conducted with a sample of 305 Spanish nurses using the online Work-Life Interaction Questionnaire (SWING) and the Perceived Stress Scale (EP-10). The findings revealed that higher levels of perceived stress were associated with increased work-to-family conflict. This conflict was further intensified among nurses working rotating shifts. In the reverse direction, from life to work, perceived stress was again a significant factor, and having children contributed to increased negative life-to-work interference. On the other hand, certain variables were linked to more positive interactions. Having a paid caregiver was associated with lower positive work-to-family interaction, whereas religious beliefs were related to more positive experiences in this domain. Finally, being a woman and having children were both associated with greater positive life-to-work interaction. This study offers a vital perspective on the complex Work–Life interaction in nursing during crises, highlighting the urgent need for structural policies that alleviate stress and conflict while enhancing well-being by recognizing the protective role of family and spirituality. These findings open new avenues for designing more effective, responsive interventions for healthcare personnel. 2025-06-04T07:11:58Z 2025-06-04T07:11:58Z 2025-05-30 journal article Antolí-Jover, A. M., Gázquez-López, M., Brieba-del Río, P., Martín-Salvador, A., Martínez-García, E., Sánchez-García, I., & Álvarez- Serrano, M. A. (2025). Prevalence and Predictors of Work–Life Balance Among Nursing Personnel During the Sixth Wave of the Pandemic: The Role of Stress and Sociodemographic and Work-Related Variables. Behavioral Sciences, 15(6), 751. https://doi.org/10.3390/bs15060751 https://hdl.handle.net/10481/104456 10.3390/bs15060751 eng http://creativecommons.org/licenses/by-nd/4.0/ open access Attribution-NoDerivatives 4.0 Internacional MDPI