Acute intraocular pressure responses changes during dynamic resistance training in primary open‑angle glaucoma patients and age‑matched controls Morenas Aguilar, María Dolores González‑Hernández, Cristina Marcos-Frutos, Daniel Miras Moreno, Sergio López‑Gómez, María José García Ramos, Amador Vera Vílchez, Jesús Leg extension Ocular health Biceps curl Supplementary Information The online version contains supplementary material available at https://doi. org/10.1007/s00417-025-06814-9 Background Physical exercise has been proposed as a feasible strategy for preventing and managing glaucoma by modulating intraocular pressure (IOP) and ocular perfusion pressure (OPP). The primary objective of this cross-sectional study was to assess the IOP and OPP responses to dynamic resistance exercises (leg extension and biceps curl). Methods Twenty-six patients with primary open-angle glaucoma (POAG) (age = 68.9 ± 8.1 years) and 18 healthy agematched controls (age = 69.6 ± 5.9 years) were recruited. Participants performed one set of 10 repetitions of both exercises at low- (light bar) and moderate-intensity (15RM). IOP and blood pressure were measured at baseline and after 1 and 5 min of passive recovery. Additionally, IOP was measured during training after each of the 10 repetitions. Results Our data showed a progressive IOP increase throughout the sets of leg extension and biceps curl exercises when performed at moderate intensity (p < 0.001). Remarkably, POAG patients showed a smaller IOP increase compared to controls (p = 0.048). The between-group differences for IOP changes were higher during the 10 exercise repetitions at moderateintensity for both leg extension (average IOP rise: POAG = 0.3 ± 0.6 mmHg vs. control = 2.3 ± 0.7 mmHg) and biceps curl (average IOP rise: POAG = 1.4 ± 0.6 mmHg vs. control = 3.4 ± 0.8 mmHg) exercises. No changes in OPP were observed. Conclusions The findings of this study suggest that moderate-intensity dynamic resistance training is a safe intervention for potentially improving physical fitness in medically treated POAG patients. 2025-05-21T08:51:04Z 2025-05-21T08:51:04Z 2025-04-17 journal article Morenas-Aguilar, M.D., González-Hernández, C., Marcos-Frutos, D. et al. Acute intraocular pressure responses changes during dynamic resistance training in primary open-angle glaucoma patients and age-matched controls. Graefes Arch Clin Exp Ophthalmol (2025). [https://doi.org/10.1007/s00417-025-06814-9] https://hdl.handle.net/10481/104167 10.1007/s00417-025-06814-9 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer Nature