Strategies for the Fortification of Human Milk in Preterm Infants: A Systematic Review Contreras Chova, Francisco Villanueva-García, Andrea González-Boyero, JL Campos Martínez, Ana Blanca Jóver, Enrique Jerez Calero, Antonio Emilio Uberos Fernández, José Breastmilk fortification Donor human milk fortification Human milk Human milk fortifiers Preterm newborns Breast milk is the best source of nourishment for both full-term and preterm newborns. However, in preterm newborns, exclusive breastfeeding can lead to nutritional deficiencies, with short- and long-term consequences on growth and neurocognitive development. Breast milk fortification is a widely used strategy to provide an adequate nutritional profile to these patients. There is currently a great heterogeneity in terms of fortification patterns and the type of fortifier. The present systematic review summarizes the current scientific evidence to evaluate the different strategies for fortification of human milk in preterm infants, their possible differences on benefits, and the hypothetical impact on prematurity outcomes. 2025-05-21T07:01:11Z 2025-05-21T07:01:11Z 2024-10-11 journal article Contreras Chova F, Villanueva-García A, González-Boyero J, et al. (November 10, 2024) Strategies for the Fortification of Human Milk in Preterm Infants: A Systematic Review. Cureus 16(11): e73380. DOI 10.7759/cureus.73380 https://hdl.handle.net/10481/104162 10.7759/cureus.73380 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Springer Nature