Impact of weight loss and lifestyle intervention on vitamin D in men with obstructive sleep apnea: The INTERAPNEA trial Vázquez Lorente, Héctor Herrera Quintana, Lourdes María Ruiz Ruiz, Jonatan Amaro Gahete, Francisco José Carneiro Barrera, Almudena Obstructive sleep apnea Obesity Weight loss Lifestyle intervention Vitamin D Sleep This study was supported by the Spanish Ministry of Education through grants provided to A.C.-B. (FPU16/01093) and F.J.A.-G. (FPU14/04172); the University of Granada-LoMonaco S.L. Sleep Research Cathedra; the University of Granada Plan Propio de Investigación 2016 –Excellence actions: Unit of Excellence on Exercise and Health (UCEES); and the Regional Ministry of Economy, Knowledge, Enterprise and Universities (CECEU) of Andalusia (European Regional Development Funds, SOMM17/6107/UGR). Introduction Vitamin D deficiency is commonly found among patients with obstructive sleep apnea (OSA). We aimed to determine the effect of an eight-week interdisciplinary weight loss and lifestyle intervention on circulating vitamin D levels in patients with moderate-to-severe OSA. Methods 89 men were assigned to a usual-care group (n = 49) or an 8-week interdisciplinary weight loss and lifestyle intervention combined with usual-care (n = 40). Evaluations were conducted at baseline, intervention endpoint (i.e., 8 weeks), and 6 months post-intervention. Serum 25-hydroxyvitamin D (25(OH)D) was determined using a chemiluminescence immunoassay. Sleep (i.e., sleep efficiency, apnea-hypopnea index [AHI], and oxygen desaturation index) and body weight and composition (i.e., fat mass, and visceral adipose tissue) variables were also determined. Results Serum 25(OH)D concentrations showed an insufficient vitamin D status at baseline, which significantly increased (all p ≤ 0.034) at intervention endpoint (19 %) and at 6 months after intervention (45 %) in the intervention group to the point of potentially resolving vitamin D deficiency. Higher serum 25(OH)D concentrations were related to increased sleep efficiency and reduced AHI, oxygen desaturation index, and body weight and composition variables (all p < 0.001) from baseline to 6 months and from 8 weeks to 6 months after intervention. These results were also noted from baseline to 8 weeks, except for body composition (all p ≤ 0.007). Conclusion The intervention improved and potentially resolved vitamin D deficiency. Together with the improvement of adverse sleep patterns and body composition parameters, it may be considered as a promising approach in the treatment of OSA. 2025-04-22T11:58:14Z 2025-04-22T11:58:14Z 2025-04 journal article H. Vázquez-Lorente et al. Sleep Medicine 128 (2025) 37–45. https://doi.org/10.1016/j.sleep.2025.01.011 https://hdl.handle.net/10481/103733 10.1016/j.sleep.2025.01.011 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Elsevier