Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia Jiménez-López, M. Carmen Moreno-Maldonado, Ana Carolina Martín Morales, Natividad O´Valle, Francisco Ibarra, M. Ricardo Goya, Gerardo F. Molina Pineda Infantas, Ignacio Jesús Magnetoliposomes Magnetic hyperthermia Cis-diamminedichloroplatinum (II) CDDP Lung tumor This work was supported by grants RTC-2017-6620-1 from the Ministry of Science and Innovation of Spain and H2020-MSCA-RISE-2020 101007629-NESTOR from the European Commision. This work is in partial fulfillment of the requirements of the University of Granada Ph.D. program in Biomedicine towards MCJL degree. There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41 °C. These methods utilize different energy sources to deliver heat to the target region, including light, microwaves or radiofrequency electromagnetic fields. We have developed a new, magnetically responsive nanocarrier, consisting of liposomes loaded with magnetic nanoparticles and cis-diamminedichloroplatinum (II) (CDDP), commonly known as Cisplatin. The resulting magnetoliposome (ML) is rapidly internalized by lung and pancreas tumor cell lines, stored in intracellular vesicles, and capable of inducing hyperthermia under magnetic fields. The ML has no significant toxicity both in vitro and in vivo and, most importantly, enhances cell death by apoptosis after magnetic hyperthermia. Remarkably, mice bearing induced lung tumors, treated with CDDP-loaded nanocarriers and subjected to an applied electromagnetic field, showed an improved survival rate over those treated with either soluble CDDP or hyperthermia alone. Therefore, our approach of magnetic hyperthermia plus CDDP-ML significantly enhances in vitro cell death and in vivo survival of treated animals. 2025-04-02T09:29:39Z 2025-04-02T09:29:39Z 2025-02-08 journal article Jiménez-López, M.C., Moreno-Maldonado, A.C., Martín-Morales, N. et al. Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia. Sci Rep 15, 4780 (2025). https://doi.org/10.1038/s41598-025-88533-z https://hdl.handle.net/10481/103397 10.1038/s41598-025-88533-z eng info:eu-repo/grantAgreement/EC/H2020/101007629 http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Springer Nature