EFINUTRILES Study: Integrative Extra Virgin Olive Oil and Multimodal Lifestyle Interventions for Cardiovascular Health and SLE Management Gil Gutiérrez, María del Rocío Medina Martínez, Irene Quesada-Caballero, Miguel Hera Fernández, Francisco Javier Zamora Pasadas, Mónica Cantarero Villanueva, Irene Albendín García, Luis Parola, Vítor Rueda Medina, Blanca María Correa Rodríguez, María Autoimmune diseases Cardiovascular Risk Extra virgin olive oil Mediterranean diet Physical exercise The following founding sources must be highlighted: Consejería de Economía, Innovación y Ciencia (Proyectos de I + D + I en el marco operativo FEDER Andalucía 2014–2020; B-CTS-100-UGR-20): BRM. University of Granada (Proyectos de investigación precompetitivos para jóvenes investigadores del Plan Propio de Investigación de la Universidad de Granada: Modalidad A-Jóvenes doctores, PPJIA2021-03): MCR. Spanish Ministry of Education and Vocational Training (FPU20/05674): RGG. Supplementary Materials. The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/nu17061076/s1 Objectives: To analyze the effects of the combination of Extra Virgin Olive Oil (EVOO) supplementation and a health-related lifestyle intervention on disease activity and cardiovascular disease risk factors in Systemic Lupus Erythematosus (SLE). Methods: A total of 38 women with SLE were randomly assigned to EVOO (n = 9) and EVOO combined with multicomponent health promotion and physical exercise program (EVOO + HRLI) (n = 15) or control (CG) (n = 14) groups for 24 weeks. Baseline and post-intervention assessments were performed, collecting data on disease activity, accrual damage, blood biochemical parameters, arterial stiffness parameters, Framingham risk score, anthropometric and body composition measurements, and cardiovascular risk factors. Results: No changes in disease activity were observed in any group after the intervention. For cardiovascular risk, significant differences were observed in the intervention groups for systolic and mean blood pressure, with greater reductions in the EVOO + HRLI (p = 0.036 vs. p < 0.001; p = 0.017 vs. p < 0.001, respectively). The EVOO group showed significant reductions in BFM and BFP (p = 0.042, p = 0.022, respectively). The EVOO+ HRLI group also showed significant reductions in triglycerides (p < 0.001), Aix brachial (p = 0.037), central systolic blood pressure (p < 0.001), central pulse pressure (p = 0.05), body mass index (p = 0.006), body fat mass and skeletal muscle mass (p = 0.039) after the intervention. Conclusions: Our findings suggest that a multidisciplinary program integrating nutritional interventions, health education, and the promotion of regular physical activity in SLE patients has the potential to significantly improve cardiovascular risk factors and body composition parameters. Thus, integrating this approach into clinical practice alongside usual pharmacological treatments would be beneficial for SLE patients. Clinical Trial Registration: NCT05261529. 2025-03-26T10:18:30Z 2025-03-26T10:18:30Z 2025-03-19 journal article Gil-Gutiérrez, R.; Medina-Martínez, I.; Quesada-Caballero, M.; de la Hera-Fernández, F.J.; Zamora-Pasadas, M.; Cantarero-Villanueva, I.; Albendín-García, L.; Parola, V.; Rueda-Medina, B.; Correa-Rodríguez, M. EFINUTRILES Study: Integrative Extra Virgin Olive Oil and Multimodal Lifestyle Interventions for Cardiovascular Health and SLE Management. Nutrients 2025, 17, 1076. https://doi.org/10.3390/nu17061076 https://hdl.handle.net/10481/103296 10.3390/nu17061076 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI