Meningococcal Vaccination in High-Risk Patients: A Systematic Approach to Evaluating Coverage and Patient Catch-Up Through Healthcare Databases Ruiz Montero, Rafael Serrano-Ortiz, Álvaro Rivera Izquierdo, Mario Galvache Murillo-Rico, Piedad Moñiz Díez, Ana Onieva García, María Ángeles Girela López, Eloy Salcedo-Leal, Inmaculada Meningococcal infections Neisseria meningitidis Vaccination Vaccination coverage Immunization programs The publication costs were funded by the research group CTS-295 in Preventive Medicine and Public Health, University of Córdoba. Background: Invasive meningococcal disease (IMD) can lead to severe and fatal outcomes. Vaccines against meningococcus (serogroups B, MenB; or ACWY, MenACWY) are recommended for patients at high risk of developing IMD. Our aim was to identify high-risk patients through a systematic search of medical codes and to evaluate vaccination coverage by high-risk group. Methods: An observational retrospective study was conducted in patients discharged at Reina Sofía University Hospital (Cordoba, Spain) from 1 January 2000, to 31 December 2023. Selection of high-risk patients was conducted through national administrative and clinical databases and vaccination coverage was determined through the Andalusian electronic vaccine database. Vaccine coverages of MenB and MenACWY were calculated within risk groups. Finally, bivariate analyses were conducted to assess the potential association between coverage, sex, and the year of admission. Results: A total of 2689 patients with 2710 high-risk conditions for IMD were identified from the databases searched. Of the 1755 requiring MenB vaccination, only 624 (35.6%) had received one dose and 558 (31.8%) two doses. Of the 2710 requiring MenACWY vaccination, only 784 (28.9%) had received one dose and 520 (19.2%) two doses. Patients with properdin-complement deficiencies showed the lowest vaccination rates (<10%). For the rest of the high-risk groups, vaccination coverages were significantly lower when the condition was diagnosed before the immunization guideline recommendations (p < 0.001). Conclusions: The identification of high-risk patients through databases using R-coded algorithms is both feasible and effective for identifying and catching-up patients for vaccination. The population at risk of IMD lacks adequate meningococcal vaccination coverage. Our methodology can serve to identify patients in other regions and for different vaccines. 2025-03-24T09:16:34Z 2025-03-24T09:16:34Z 2025-03-08 journal article Ruiz-Montero, R.; Serrano-Ortiz, Á.; Rivera-Izquierdo, M.; Galvache Murillo-Rico, P.; Moñiz-Díez, A.; Onieva-García, M.Á.; Girela-López, E.; Salcedo-Leal, I. Meningococcal Vaccination in High-Risk Patients: A Systematic Approach to Evaluating Coverage and Patient Catch-Up Through Healthcare Databases. Vaccines 2025, 13, 287. https://doi.org/10.3390/vaccines13030287 https://hdl.handle.net/10481/103263 10.3390/vaccines13030287 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI