Diet, Advanced Maternal Age, and Neonatal Outcomes: Results from the GESTAGE Study Puche-Juárez, María Toledano, Juan M Hinojosa Nogueira, Daniel José De Paco Matallana, Catalina Sanchez-Romero, Javier Ochoa Herrera, Julio José Carrillo, María Paz Martín-Álvarez, Estefanía Díaz Castro, Javier Moreno Fernández, Jorge Pregnant women Pregnancy Advanced maternal age Dietary recommendations Early nutrition This study was supported by Consejería de transformación económica, industria, comiento y universidades. Junta de Andalucía, “Proyectos de Investigación de Excelenciadel Plan Andaluz de Investigación” (PAIDI 2020) (P21_00040); by two differents projects from “Proyectos de Investigación Precompetitivos del Plan Propio 2022, University of Granada” (PPJIA2022-31; PP2022, PP-07) and by “Programa Operativo FEDER Andalucía” (B-CTS-UGR20) and by “Proyectos de investigación I + D + I del Plan Propio de Investigación y Transferencia de la Universidad de Granada en el marco del Programa Operativo FEDER Andalucía 2021-2027” (C-CTS-361-UGR23). Biobank Network of the Region of Murcia (BIOBANC-MUR), registered in the “Registro Nacional de Biobancos” of Spain, with a registration number B.0000859. BIOBANC-MUR is supported by the “Instituto de Salud Carlos III (project PT20/00109), by “Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca” and by “Consejeria de Salud de la Comunidad Autónoma de la Región de Murcia”. Maternal nutrition during pregnancy plays a pivotal role in influencing both maternal and fetal health, impacting neonatal anthropometric outcomes and long-term disease susceptibility. An advanced maternal age (AMA ≥ 35 years) has been linked to increased risks of obstetric complications and adverse neonatal outcomes, yet its specific nutritional profile remains underexplored. Background/Objectives: This study aimed to evaluate the nutrient and polyphenol intakes of women at an AMA compared to those of a younger control group and to investigate associations with neonatal anthropometric measures. Methods: A cohort of 200 pregnant women, stratified into AMA and control groups, completed a food frequency questionnaire during the second trimester. Neonatal anthropometric data were collected at delivery. Results: Intakes of fiber, zinc, copper, selenium, vitamins E, B1, B3 and folate were lower in the AMA group in comparison with the control values. Negative correlations were found between fiber, vitamin A and vitamin E and the head circumference of the newborn, with fiber being identified as a potential predictor of this parameter. Conclusions: Despite some limitations, such as the fact that the FFQ was completed only once during pregnancy and the cross-sectional design of the study, the findings highlight notable nutritional deficiencies among AMA women, which may influence neonatal outcomes such as head circumference. These results underscore the need for nutritional guidelines and supplementation strategies tailored to pregnant women over 35 years of age. 2025-03-20T11:34:26Z 2025-03-20T11:34:26Z 2025-01-17 journal article Puche-Juarez, M.; Toledano, J.M.; Hinojosa-Nogueira, D.; de Paco Matallana, C.; Sánchez-Romero, J.; Ochoa, J.J.; Carrillo, M.P.; Martín-Álvarez, E.; Diaz-Castro, J.; Moreno-Fernandez, J. Diet, Advanced Maternal Age, and Neonatal Outcomes: Results from the GESTAGE Study. Nutrients 2025, 17, 321. https://doi.org/10.3390/nu17020321 https://hdl.handle.net/10481/103202 10.3390/nu17020321 eng http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional MDPI