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      <dc:title>Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature</dc:title>
      <dc:creator>Martínez Galán, Joaquina</dc:creator>
      <dc:creator>Jiménez Luna, Cristina</dc:creator>
      <dc:creator>Rodríguez, Isabel</dc:creator>
      <dc:creator>Maza, Elisabeth</dc:creator>
      <dc:creator>García Collado, Carlos</dc:creator>
      <dc:creator>Rodríguez Fernández, Antonio</dc:creator>
      <dc:creator>López Hidalgo, Javier Luis</dc:creator>
      <dc:creator>Caba Pérez, Octavio</dc:creator>
      <dc:subject>Pancreatic ductal adenocarcinoma</dc:subject>
      <dc:subject>Lung cancer;</dc:subject>
      <dc:subject>Immunotherapy</dc:subject>
      <dc:subject>Pembrolizumab</dc:subject>
      <dc:subject>Programmed cell death protein- 1</dc:subject>
      <dc:subject>Case report</dc:subject>
      <dc:description>María Zambrano postdoctoral fellowship funded by the Spanish Ministry of Universities and Next Generation European Union.</dc:description>
      <dc:description>The lack of specific symptoms in patients and the absence of a reliable and well-stablished diagnostic method,&#xd;
makes advanced pancreatic ductal adenocarcinoma (PDAC) the most common clinical appearance of pancreatic cancer&#xd;
cases. In these circumstances, surgical resection, the only curative approach for this malignancy, is unaffordable, leading to&#xd;
very low survival outcomes. Immunotherapy is a recent approach that has been studied in many cancer types showing&#xd;
encouraging results, but it has not been sufficiently investigated in PDAC. We report the case of a patient with unresectable&#xd;
PDAC that progressed to metastasis after treatment with chemoradiation, who showed an outstanding response to immuno-&#xd;
therapy with pembrolizumab, achieving a complete remission within a few months, which was maintained until the end of&#xd;
treatment. Currently, the patient continues in disease-free state.</dc:description>
      <dc:date>2025-03-13T12:50:12Z</dc:date>
      <dc:date>2025-03-13T12:50:12Z</dc:date>
      <dc:date>2024-05-15</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Martínez-Galán, J., Jiménez-Luna, C., Rodriguez, I., Maza, E., García-Collado, C., Rodríguez-Fernández, A., López-Hidalgo, J. L., &amp; Caba, O. (2024). Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature. World journal of gastrointestinal oncology, 16(5), 2233–2240. https://doi.org/10.4251/wjgo.v16.i5.2233</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/103047</dc:identifier>
      <dc:identifier>10.4251/wjgo.v16.i5.2233</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/3.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License</dc:rights>
      <dc:publisher>Baishideng Publishing Group Inc.</dc:publisher>
   </ow:Publication>
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