<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/102739">
      <dc:title>Plant-Derived Molecules Modulate Multidrug Resistance in Gastrointestinal Cancers: A Comprehensive Review</dc:title>
      <dc:creator>Perazzoli, Gloria</dc:creator>
      <dc:creator>Mesas, Cristina</dc:creator>
      <dc:creator>Quiñonero Muñoz, Francisco José</dc:creator>
      <dc:creator>Doello, Kevin</dc:creator>
      <dc:creator>Peña Contreras, María Mercedes</dc:creator>
      <dc:creator>Cepero, Ana</dc:creator>
      <dc:creator>Rodríguez Criado, Jorge</dc:creator>
      <dc:creator>Prados Salazar, José Carlos</dc:creator>
      <dc:creator>Melguizo Alonso, Consolación</dc:creator>
      <dc:subject>multidrug resistance</dc:subject>
      <dc:subject>gastrointestinal cancer</dc:subject>
      <dc:subject>natural products</dc:subject>
      <dc:description>Multidrug resistance (MDR) development against cytotoxic drugs by tumor cells&#xd;
is one of the main causes of treatment failure in gastrointestinal cancers, a group of cancers&#xd;
of great relevance due to their prevalence and/or mortality. This phenomenon is mediated&#xd;
by diverse mechanisms, including the overexpression of members of the superfamily of&#xd;
membrane transporters of the ATP-binding cassette (ABC). Most of these molecules, including&#xd;
P-glycoprotein (P-gp or MDR1/ABCB), MDR-associated protein 1 (MRP1/ABCC1),&#xd;
MRP2, and breast cancer resistance protein (BCRP/ABCG2), are integrated in the cell&#xd;
membrane, acting as drug efflux pumps. Despite the use of various MDR modulators as&#xd;
adjuvants to improve the chemotherapy response, the results have not been satisfactory.&#xd;
Natural products from plants, such as flavonoids, alkaloids, terpenoids, and coumarins, are&#xd;
capable of modifying drug resistance, suggesting an improvement in the antitumoral effect&#xd;
of the current treatments without generating side effects. This review aims to provide an&#xd;
overview of the most recent studies in relation to plant-derived molecules and extracts that&#xd;
modulate resistance to antitumor drugs and that could be applied in the future in clinical&#xd;
practice to improve the treatment of patients with gastrointestinal cancer.</dc:description>
      <dc:date>2025-02-26T12:20:29Z</dc:date>
      <dc:date>2025-02-26T12:20:29Z</dc:date>
      <dc:date>2025-01-23</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Perazzoli, G.; Mesas, C.; Quiñonero, F.; Doello, K.; Peña, M.; Cepero, A.; Rodríguez-Criado, J.; Prados, J.; Melguizo, C. Plant-Derived Molecules Modulate Multidrug Resistance in Gastrointestinal Cancers: A Comprehensive Review. Appl. Sci. 2025, 15, 1125. https://doi.org/ 10.3390/app15031125</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/102739</dc:identifier>
      <dc:identifier>10.3390/app15031125</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>