Hearing loss rather than vestibular loss identifies patient subgroups with different outcomes in Meniere’s disease Zhang, Yuzhong López Escámez, José Antonio Meniere’s disease Hearing Vestibular function Duration Clinical characteristics Qing Zhang has received funds to support the research from the National Natural Science Foundation of China (Grant No. 82471160, 82171137) and the Medicine-Science and Engineering Interdisciplinary Foundation of Shanghai Hospital Development Centre (Grant No. SHDC2022CRD013). Shanghai Jiao Tong University School of Medicine Affiliated Xinhua Hospital Project (Grant No. 23XHCR05A). Jose A Lopez-Escamez has received funds to support research on MD from The University of Sydney (K7013_B3413 Grant), Asociación Sindrome de Meniere España (ASMES) and Meniere’s Society, UK. Objective This study investigates the relationship between Meniere’s disease (MD) duration and both hearing thresholds and vestibular dysfunction. Design Retrospective cohort study. First, the relationships between MD duration and pure-tone audiometry thresholds for each frequency, the canal paresis (CP) ratio, and the vestibulo-ocular reflex (VOR) gain were analysed. Second, clinical characteristics, CP values, and VOR gains were compared between patient groups with low and high hearing thresholds to determine whether they exhibited different clinical presentations. Study sample The study included 69 patients diagnosed with unilateral MD within a duration of 10 years. A hearing dataset from 306 MD Spanish patients was used to cluster patients according to the hearing profile overtime. Results The thresholds at 250–2000 Hz frequencies increased with the duration of the disease. Conversely, vestibular function tests were not related to the duration of MD. Additionally, no statistically significant differences were observed in clinical characteristics, CP values, or VOR gain between patient groups with low and high hearing thresholds. Conclusions Hearing loss involves all frequencies in most patients and hearing outcome, rather than vestibular loss, may define patient subgroups in MD. Moreover, not all patients with MD experience hearing loss progression as the duration of the disease increases. 2025-02-25T13:25:39Z 2025-02-25T13:25:39Z 2025-01-13 journal article Zhang, Y., Wu, Q., Liu, L., Zhao, Y., Dai, Q., Lopez-Escamez, J. A., & Zhang, Q. (2025). Hearing loss rather than vestibular loss identifies patient subgroups with different outcomes in Meniere’s disease. International Journal of Audiology, 1–7. https://doi.org/10.1080/14992027.2025.2450657 https://hdl.handle.net/10481/102682 10.1080/14992027.2025.2450657 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Taylor and Francis