Assessment of halloysite nanotubes as vehicles of isoniazid Carazo, Esperanza Borrego-Sánchez, Ana García-Villén, Fátima Sánchez-Espejo, Rita Aguzzi , Carola Viseras, César Sainz-Díaz, Claro Ignacio Cerezo, Pilar Isoniazid Halloysite Adsorption Thermodynamics Molecular modeling Nanohybrids Equilibrium and thermodynamic aspects of the adsorption of isoniazid (INH) onto halloysite nanotubes (HLNTs) and characteristics of the resultant drug/nanocarrier systems are investigated. Equilibrium studies were performed in aqueous medium at different times, temperatures and drug concentrations. The overall adsorption process was explained as the result of two simple processes: adsorption on the activated sites of HLNTs and precipitation of INH on HLNTs surface. Formation of the INH-loaded HLNTs was spontaneous, endothermic and endoentropic, increasing the thermodynamic stability of the system (ΔH = 70.40 kJ/mol; ΔS = 0.2519 kJ/molK). Solid state characterization corroborated the effective interaction between the components that was also described by modeling at molecular level by quantum mechanics calculations along with empirical interatomic potentials. Transmission electron microphotographs confirmed the double allocation and homogeneous distribution of INH in the nanohybrids. FTIR spectra revealed the interaction via hydrogen bonds between the inner hydroxyl groups of HLNTs and N in INH molecules. Loading of INH in the nanohybrids was approximately 20% w/w. Effective loading of INH and activation energies of the interactions enable to propose the designed nanohybrids in the development of modified drug delivery systems. 2025-02-03T11:59:30Z 2025-02-03T11:59:30Z 2017 journal article Carazo, E., Borrego-Sánchez, A., García-Villén, F., Sánchez-Espejo, R., Aguzzi, C., Viseras, C., Sainz-Díaz, C.I., Cerezo, P. (2017). Assessment of halloysite nanotubes as vehicles of isoniazid. Colloids and Surfaces B: Biointerfaces, 160, 337-344 https://hdl.handle.net/10481/101905 10.1016/j.colsurfb.2017.09.036 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ embargoed access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License