Natural products: Perspectives in the pharmacological treatment of gastrointestinal anisakiasis Valero López, Adela Romero López, María del Carmen Gómez-Mateos, Magdalena Hierro Marín, Ignacio Navarro Moll, María Concepción Anisakis Anisakiasis Natural products Essential oils Terpenic derivatives Objective To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search (using Pubmed, Scopus, Medline, Web of Science and ScienceDirect). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products (plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. 2025-02-02T06:09:35Z 2025-02-02T06:09:35Z 2015-07-22 journal article A. Valero, M.C. Romero, M. Gómez-Mateos, I. Hierro, M.C. Navarro, Natural products: Perspectives in the pharmacological treatment of gastrointestinal anisakiasis, Asian Pacific Journal of Tropical Medicine, Volume 8, Issue 8, 2015, Pages 612-617, ISSN 1995-7645, https://doi.org/10.1016/j.apjtm.2015.07.017. (https://www.sciencedirect.com/science/article/pii/S1995764515000942) https://hdl.handle.net/10481/101764 https://doi.org/10.1016/j.apjtm.2015.07.017 eng open access Elsevier