Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems de Jesus Oliveira, Antônia Carla Luíse, Lopes Chaves de Oliveira Silva Ribeiro, Fabio Monteiro de Lima, Laís Ramos Cardoso de Oliveira, Thaisa García-Villén, Fátima Viseras, César C. M. de Paula, Regina Rolim-Neto, Pedro José Hallwass, Fernando Silva-Filho, Edson C. Alves da Silva, Durcilene Soares-Sobrinho, José Lamartine de La Roca Soares, Mônica Felts Chemical modification of polysaccharides is an important approach for their transformation into customized matrices that suit different applications. Microwave irradiation (MW) has been used to catalyze chemical reactions. This study developed a method of MW-initiated synthesis for the production of phthalated cashew gum (Phat-CG). The structural characteristics and physicochemical properties of the modified biopolymers were investigated by FTIR, GPC, 1H NMR, relaxometry, elemental analysis, thermal analysis, XRD, degree of substitution, and solubility. Phat-CG was used as a matrix for drug delivery systems using benznidazole (BNZ) as a model drug. BNZ is used in the pharmacotherapy of Chagas disease. The nanoparticles were characterized by size, PDI, zeta potential, AFM, and in vitro release. The nanoparticles had a size of 288.8 nm, PDI of 0.27, and zeta potential of –31.8 mV. The results showed that Phat-CG has interesting and promising properties as a new alternative for improving the treatment of Chagas disease. 2025-02-01T10:57:50Z 2025-02-01T10:57:50Z 2021 journal article Carbohydrate Polymers https://hdl.handle.net/10481/101719 10.1016/j.carbpol.2020.117226 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ embargoed access Attribution-NonCommercial-NoDerivatives 4.0 Internacional