Targeted retroviral infection of tumor cells by receptor co-operation Martin, Francisco Chowdhury, Simon Neil, Stuart chester, k Cosset, Francois collins, mary targeting gene therapy tumor cells receptor cooperation envelope Retroviruses expressing two different receptor-binding domains linked by proline-rich spacers infect only cells expressing both retroviral receptors (Valsesia-Wittman et al., EMBO J. 6:1214-1223, 1997). Here we apply this receptor cooperation strategy to target human tumor cells by linking single-chain antibodies recognizing tumor antigens via proline-rich spacers to the 4070A murine leukemia virus surface protein. 2025-01-31T08:31:20Z 2025-01-31T08:31:20Z 2003 journal article Journal of Virology. Vol 77(4); Págs: 2753-2756 (2003) https://hdl.handle.net/10481/101488 10.1128/jvi.77.4.2753-2756.2003 eng open access AMERICAN SOCIETY OF MICROBIOLOGY