In vitro and in vivo activity of three sesquiterpenes against L3 larvae of Anisakis type I Navarro Moll, María Concepción Romero López, María del Carmen Montilla Herrera, María Del Pilar Valero López, Adela Anisakis Anisakiasis Sesquiterpenes Nerolidol Elemol Nutrition education In order to investigate the possible use of terpenic derivatives to treat anisakiasis caused by L3 larvae of Anisakis, we studied the in vitro and in vivo larvicidal activity of three sesquiterpenes (nerolidol, farnesol and elemol). In vitro experiments included the histological study of larval damage and in vivo studies the measurement of myeloperoxidase activity in rat gastrointestinal tract after administration of the sesquiterpenes. In the in vitro assays, the most active compound against the L3 larvae was nerolidol, followed by farnesol; both caused the death of all nematodes, which showed cuticle changes and intestinal wall rupture. In the in vivo assays, only 20% of infected rats treated with nerolidol or farnesol showed gastric wall lesions in comparison to 86.6% of control animals. According to these results, nerolidol and farnesol are good candidates for further research as biocidal agents against L3 larvae of Anisakis type I 2025-01-31T07:28:18Z 2025-01-31T07:28:18Z 2010-09-21 journal article M Concepción Navarro-Moll, M Carmen Romero, M Pilar Montilla, Adela Valero, In vitro and in vivo activity of three sesquiterpenes against L3 larvae of Anisakis type I, Experimental Parasitology, Volume 127, Issue 2, 2011, Pages 405-408, ISSN 0014-4894, https://hdl.handle.net/10481/101399 10.1016/j.exppara.2010.09.008 eng open access Elsevier