Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans Gomez-Banoy, Nicolas Guseh, J Sawalla Li, Ge Chen, Tong Poirier, BreAnne Putzel, Gregory Rosselot, Carolina Pabon, Maria A Camporez, João Paulo Vijeta, Bhambhani Shih-Jen, Hwang Chen, Yao Perry, Rachel J Sushmita, Mukherjee Larson, Martin G Levy, Daniel Dow, Lukas E Shulman, Gerald I Dephoure, Noah Garcia-Ocaña, Adolfo Hao, Mingming Spiegelman, Bruce M Ho, Jennifer E Lo, James C Rubio-Navarro, Alfonso N.G.­B. is supported by an American Diabetes Association postdoctoral fellowship (1­18­PMF­032). J.S.G. was supported by an MGH NIH T32 Training Grant (HL007208), the John S. LaDue Memorial Fellowship and the MGH Physician Scientist Development Program. This work was supported by a Weill Cornell Department of Medicine Seed Grant for Innovative Research to J.C.L., the JPB Foundation (to B.M.S.), Jill Roberts IBD Institute (to G.P.) and NIH grants DK097303 (to J.C.L.), R03 DK111762 (to J.C.L.), R01 DK121844 (to J.C.L.), R01 HL140224 (to J.E.H.) and R01 HL134893 (to J.E.H.). This work was partially supported by the National Heart, Lung and Blood Institute’s Framingham Heart Study (contracts N01­HC­25195 and HHSN268201500001I) and by the Division of Intramural Research (to P.C., G.S., C.L., S.­J.H. and D.L.) of the National Heart, Lung and Blood Institute. We acknowledge support from the Yale Mouse Metabolic Phenotyping Center via NIH grants nos. U24 DK­059635, R01 DK116774, R01 DK114793 and P30 DK045735 (all to G.I.S.). 2025-01-27T13:01:21Z 2025-01-27T13:01:21Z 2019-11-25 journal article Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC. Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nat Med. 2019 Nov;25(11):1739-1747. doi: 10.1038/s41591-019-0610-4. Epub 2019 Nov 7. PMID: 31700183; PMCID: PMC7256970. https://hdl.handle.net/10481/100605 10.1038/s41591-019-0610-4 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ open access Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Springer Nature