Bone health in children and youth with cystic fibrosis: a systematic review and meta-analysis of matched cohort studies Ubago Guisado, Esther Cavero Redondo, Iván Alvarez Bueno, Celia Vlachopoulos, Dimitris Martínez Vizcaíno, Vicente Gracia Marco, Luis Andrés adolescence bone mass densitometry pediatric youth Objective: To assess the evidence regarding the differences in areal bone mineral density (aBMD) between children and adolescents with cystic fibrosis (CF) compared with their healthy peers, based on data from longitudinal studies. Study design: We searched MEDLINE, SPORTDiscus, the Cochrane Library, PEDro (Physiotherapy Evidence Database), and Embase databases. Observational studies addressing the change of aBMD in children with CF and healthy children and adolescents were eligible. The DerSimonian and Laird method was used to compute pooled estimates of effect sizes (ES) and 95% CIs for the change of whole body (WB), lumbar spine (LS), and femoral neck (FN) aBMD. Results: Six studies with participants with CF and 26 studies with healthy participants were included in the systematic review and meta-analysis. For the analysis in children with CF, the pooled ES for the change of WB aBMD was 0.29 (95% CI -0.15 to 0.74), for the change of LS aBMD was 0.13 (95% CI -0.16 to 0.41), and for the change of FN aBMD was 0.09 (95% CI -0.39 to 0.57). For the analysis in healthy children, the pooled ES for the change of WB aBMD was 0.37 (95% CI 0.26-0.49), for the change of LS aBMD was 0.13 (95% CI -0.16 to 0.41), and for the change of FN aBMD was 0.52 (95% CI 0.19-0.85). Conclusions: aBMD development might not differ between children and adolescents with CF receiving medical care compared with their healthy peers. Further longitudinal studies in a CF population during growth and development are required to confirm our findings. 2025-01-23T07:28:26Z 2025-01-23T07:28:26Z 2019 journal article Ubago-Guisado, E., Cavero-Redondo, I., Alvarez-Bueno, C., Vlachopoulos, D., Martinez-Vizcaino, V., & Gracia-Marco, L. (2019). Bone health in children and youth with cystic fibrosis: a systematic review and meta-analysis of matched cohort studies. The Journal of Pediatrics, 215, 178-186. https://hdl.handle.net/10481/100039 doi: 10.1016/j.jpeds.2019.07.073 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional