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dc.contributor.authorMora González, José 
dc.contributor.authorMigueles, Jairo H.
dc.contributor.authorEsteban Cornejo, Irene 
dc.contributor.authorCadenas Sánchez, Cristina 
dc.contributor.authorPastor-Villaescusa, Belén
dc.contributor.authorMolina-García, Pablo 
dc.contributor.authorRodríguez Ayllon, María
dc.contributor.authorRico, María C.
dc.contributor.authorGil Hernández, Ángel 
dc.contributor.authorAguilera García, Concepción María 
dc.contributor.authorEscolano-Margarit, Maria Victoria
dc.contributor.authorGejl, Anne Kaer
dc.contributor.authorAndersen, Lars Bo
dc.contributor.authorCatena Martínez, Andrés 
dc.contributor.authorOrtega Porcel, Francisco Bartolomé 
dc.date.accessioned2025-01-21T10:15:52Z
dc.date.available2025-01-21T10:15:52Z
dc.date.issued2019-11
dc.identifier.citationMora-Gonzalez J, Migueles JH, Esteban-Cornejo I, Cadenas-Sanchez C, Pastor-Villaescusa B, Molina-García P, Rodriguez-Ayllon M, Rico MC, Gil A, Aguilera CM, Escolano-Margarit MV, Gejl AK, Andersen LB, Catena A, Ortega FB. Sedentarism, Physical Activity, Steps, and Neurotrophic Factors in Obese Children. Med Sci Sports Exerc. 2019 Nov;51(11):2325-2333. doi: 10.1249/MSS.0000000000002064. PMID: 31634295.es_ES
dc.identifier.urihttps://hdl.handle.net/10481/99815
dc.description.abstractPurpose: This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors. Methods: A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant wrist. Estimates of light, moderate, vigorous, and moderate-to-vigorous PA (MVPA) were obtained. Steps per daytime, peak 60-, 30-, and 1-min cadence were computed. The time accumulated (min·d) in different cadence bands of steps was also computed from hip accelerometer. Plasma levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin growth factor-1 (IGF-1) were determined by the XMap technology (Luminex IS 100/200 system, Luminex Corporation, Austin, TX). Results: Light PA, moderate PA, MVPA, and the peak 60-min cadence were positively related with BDNF concentrations (all P < 0.05), and only light PA to VEGF (P = 0.048). No association was observed for IGF-1 (P > 0.05). The associations of light PA with BDNF and VEGF disappeared (all P > 0.05) after performing analyses with nondominant wrist-placement data. However, moderate PA and MVPA remained significantly associated with BDNF (both P < 0.05). The time accumulated in cadence bands of 40 to 59 steps per day and 60 to 79 steps per day (i.e., walking at slow pace) was positively associated with plasma BDNF (all P < 0.05). Conclusions: In conclusion, PA is positively related to plasma BDNF, whereas no relationship was observed for VEGF or IGF-1. Higher amounts of time spent in slow walking cadence bands could increment BDNF levels. Exercise-based randomized controlled trials in children with overweight/obesity should be carried out to better understand the influence of PA behaviors on the neurotrophic factors.es_ES
dc.description.sponsorshipThe ActiveBrains project was funded by the Spanish Ministry of Economy and Competitiveness/FEDER (DEP2013-47540, DEP2016-79512-R, RYC-2011-09011). J. M.-G. and J. H. M. are supported by the Spanish Ministry of Education, Culture and Sport (FPU14/06837 and FPU15/02645, respectively). I. E.-C. is supported by a grant from the Alicia Koplowitz Foundation. C. C.-S. is supported by a grant from the Spanish Ministry of Economy and Competitiveness (BES-2014-068829). P. M.-G. is supported by a grant from European Union’s Horizon 2020 research and innovation program (no 667302). Additional support was obtained from the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence, Unit of Excellence on Exercise and Health (UCEES); and by the Junta de Andalucía,Conserjería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF) (ref. SOMM17/6107/UGR). In addition, funding was provided by the SAMID III network, RETICS, funded by the PN I + D + I 2017–2021 (Spain), ISCIII—Sub-Directorate General for Research Assessment and Promotion, the European Regional Development Fund (ERDF) (ref. RD16/0022) and the EXERNET Research Network on Exercise and Health in Special Populations (DEP2005–00046/ACTI). The authors would like to thank all the families participating in the ActiveBrains project. The authors also acknowledge everyone who helped with the data collection and all of the members involved in the field-work for their effort, enthusiasm, and support. This work is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. The results of the present study do not constitute endorsement by ACSM. The authors declare that the results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.es_ES
dc.language.isoenges_ES
dc.publisherLippincott Williams & Wilkinses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectACCELEROMETRYes_ES
dc.subjectBDNFes_ES
dc.subjectCOGNITIONes_ES
dc.subjectOBESITY es_ES
dc.subjectWALKINGes_ES
dc.subjectYOUTHes_ES
dc.titleSedentarism, Physical Activity, Steps, and Neurotrophic Factors in Obese Childrenes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1249/MSS.0000000000002064
dc.type.hasVersionSMURes_ES


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