Microglial Phagocytosis During Embryonic and Postnatal Development
Metadatos
Mostrar el registro completo del ítemAutor
Marín Teva, José Luis; Sepúlveda Justo, María Del Rosario; Neubrand, Veronika Elisabeth; Cuadros Ojeda, Miguel ÁngelEditorial
Springer Nature Switzerland AG
Materia
Development Engulfment-promoted cell death Microglia Phagocytosis Phagoptosis Synaptic pruning
Fecha
2024Referencia bibliográfica
Adv Neurobiol 37:151-161
Resumen
Microglia play decisive roles during the development of the central nervous system (CNS). Phagocytosis is one of the classical functions attributed to microglia, being involved in nearly all phases of the embryonic and postnatal development of the brain, such as rapid clearance of cell debris to avoid an inflammatory response, controlling the number of neuronal and glial cells or their precursors, contribution to axon guidance and to refinement of synaptic connections. To carry out all these tasks, microglial cells are equipped with a panoply of receptors, that convert microglia to the "professional phagocytes" of the nervous parenchyma. These receptors are modulated by spatiotemporal cues that adapt the properties of microglia to the needs of the developing CNS. Thus, in this chapter, we will discuss the role of microglial phagocytosis in all the aforementioned processes. First, we will explain the general phagocytic process, to describe afterward the performance of microglial cells in detail.