Cannabidiol effects in stem cells: A systematic review
Metadatos
Mostrar el registro completo del ítemAutor
Mesas Hernández, Cristina; Moreno, Javier; Doello, Kevin; Peña Contreras, María Mercedes; López Romero, Juan Manuel; Prados Salazar, José Carlos; Melguizo Alonso, ConsolaciónEditorial
Wiley Online Library
Materia
stem cellscancer stem cells CBD in vitro in vivo
Fecha
2024-12-09Referencia bibliográfica
Mesas Hernández, C. et. al. BioFactors. 2024;1–23. [https://doi.org/10.1002/biof.2148]
Patrocinador
Spanish Ministry of Science, Innovation and Universities, Grant/Award Number: RTC2019-006870-1; Universidad de Granada/CBUAResumen
Stem cells play a critical role in human tissue regeneration and repair. In addition,
cancer stem cells (CSCs), subpopulations of cancer cells sharing similar
characteristics as normal stem cells, are responsible for tumor metastasis and
resistance to chemo- and radiotherapy and to tumor relapse. Interestingly, all
stem cells have cannabinoid receptors, such as cannabidiol (CBD), that perform
biological functions. The aim of this systematic review was to analyze the
effect of CBD on both somatic stem cells (SSCs) and CSCs. Of the 276 articles
analyzed, 38 were selected according to the inclusion and exclusion criteria. A
total of 27 studied the effect of CBD on SSCs, finding that 44% focused on CBD
differentiation effect and 56% on its protective activity. On the other hand,
11 articles looked at the effect of CBD on CSCs, including glioblastoma (64%),
lung cancer (27%), and breast cancer (only one article). Our results showed
that CBD exerted a differentiating and protective effect on SCCs. In addition,
this molecule demonstrated an antiproliferative effect on some CSCs, although
most of the analyses were performed in vitro. Therefore, although in vivo studies
should be necessary to justify its clinical use, CBD and its receptors could
be a specific target to act on both SSCs and CSCs.