Epidemiology of human papillomavirus-associated anogenital cancers in Granada: a three-decade population-based study
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Dabán-López, Pablo; Fernández Martínez, Nicolás Francisco; Petrova, Dafina; Rodríguez Barranco, Miguel; Jiménez-Moléon, José Juan; Gutierrez, Javier; Sánchez, María-JoséEditorial
Frontiers Media
Materia
human papillomavirus anogenital cancer epidemiology
Fecha
2023-09-14Referencia bibliográfica
Dabán López, P. et. al. Front. Public Health 11:1205170. [https://doi.org/10.3389/fpubh.2023.1205170]
Patrocinador
Ministry of Economy and Competitiveness and the National Institute of Health: Instituto de Salud Carlos III (ISCIII) - PI18/01593 EU/FEDER; Asociación Española Contra el Cáncer (AECC) (PROYE20023SÁNC)Resumen
Introduction: HPV infection is a common risk factor for all anogenital cancers.
However, there are important differences in the epidemiology of anogenital
cancers and these have not been compared considering diverse epidemiological
indicators over a long period of time. To fill this gap, we investigated incidence,
mortality, and survival trends of anogenital cancers over a period of three decades.
Methods: We conducted an observational registry-based study using data from
the population-based cancer registry of Granada in southern Spain. We collected
data on all incident cases of anogenital cancer (cervical, anal, penile, vulvar, and
vaginal cancer) diagnosed between 1985 and 2017. We calculated crude and
age-standardized incidence and mortality rates, and 1, 3, and 5-year overall and
net survival. We further conducted time-trend analysis calculating annual percent
changes (APC) for each cancer site.
Results: The incidence of anogenital cancers decreased slightly during the past 30
years, with the exception of vulvar cancer, where a slight increase was observed.
Mortality decreased significantly for cervical cancer over the study period but
increased non-significantly for the remaining cancer sites. Survival rates were
similar to those reported in comparable countries and increased for cervical and
vulvar cancer.
Discussion: Cervical cancer was the greatest contributor to the burden of
anogenital cancers and showed a marked improvement in all indicators in
comparison to the remaining cancer sites.