Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats
Metadatos
Afficher la notice complèteAuteur
Segarra, Ana B.; Prieto, Isabel; Martínez Cañamero, Magdalena; de Gasparo, Marc; Luna Del Castillo, Juan De Dios; Ramírez Sánchez, ManuelEditorial
Frontiers Media
Materia
aminopeptidases angiotensinases euthyroid
Date
2018-11-30Referencia bibliográfica
Segarra, A.B. et. al. Front. Endocrinol. 9:731. [https://doi.org/10.3389/fendo.2018.00731]
Patrocinador
Junta de Andalucía through PAI CVI-221 (Peptides and Peptidases)Résumé
Thyroid disorders affect the hypothalamic-pituitary-adrenal axis with important
consequences on the cardiovascular function in which the renin-angiotensin system
plays a major role. Hypo and hyperthyroidism influence the classic main components
of the renin-angiotensin system. However, the behavior of other elements of the
renin-angiotensin system such as Ang III, Ang 2-10, Ang IV, or AT4, regulated by
angiotensinase enzymes such as alanyl- (AlaAP), cystinyl- (CysAP), glutamyl- (GluAP),
or aspartyl-aminopeptidase (AspAP), has not yet been described. In order to obtain
a comprehensive view on the response of the renin-angiotensin system in the
hypothalamic-pituitary-adrenal axis of animals with thyroid disorders, these enzyme
activities were simultaneously analyzed fluorometrically, using arylamide derivatives as
substrates in hypothalamus, anterior and posterior pituitary, adrenals and plasma of
euthyroid, hypothyroid, and hyperthyroid rats, and their intra- and inter-tissue correlations
were evaluated. The response is depending on the type of enzyme studied, its location
and the thyroid status. Anterior pituitary, adrenals and plasma were mainly affected by
the thyroid disorders. In the anterior pituitary, GluAP and AspAP increased in hypothyroid
rats. In adrenals, AlaAP and CysAP decreased in hypothyroid whereas GluAP and
AspAP decreased in hyperthyroid rats. In plasma, while AlaAP increased in hypo- and
hyperthyroid rats, CysAP and GluAP decreased only in hyperthyroid. In comparison with
euthyroid, intra-tissue correlations decreased in hypothyroid but inter-tissue correlations
decreased mainly in hyperthyroid rats. Thyroid disorders also produced a disruption
in the pattern of inter-tissue correlations observed in euthyroid. These results suggest
that thyroid hormone levels hit components of the renin-angiotensin system and may
influence the paracrine and endocrine cross talk between cells.