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dc.contributor.authorHuang, Tien-Chi
dc.contributor.authorWang, Yi-Fang
dc.contributor.authorVázquez-Ferrer, Eric
dc.contributor.authorRequena Torres, Cristina Elena 
dc.contributor.authorHanna, Courtney W.
dc.contributor.authorKelsey, Gavin
dc.contributor.authorHajkova, Petra
dc.date.accessioned2024-09-27T11:11:21Z
dc.date.available2024-09-27T11:11:21Z
dc.date.issued2021-12-08
dc.identifier.citationPublished version: Huang, TC., Wang, YF., Vazquez-Ferrer, E. et al. Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature 600, 737–742 (2021). https://doi.org/10.1038/s41586-021-04208-5es_ES
dc.identifier.urihttps://hdl.handle.net/10481/95211
dc.descriptionMRC London Institute of Medical Sciences (LMS), London, UK. Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK.es_ES
dc.description.abstractStability of the epigenetic landscape underpins maintenance of the cell-type-specific transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation has been shown to be important for long-term gene silencing; its loss leads to ectopic and aberrant transcription in differentiated cells and cancer1. The developing mouse germ line endures global changes in DNA methylation in the absence of widespread transcriptional activation. Here, using an ultra-low-input native chromatin immunoprecipitation approach, we show that following DNA demethylation the gonadal primordial germ cells undergo remodelling of repressive histone modifications, resulting in a sex-specific signature in mice. We further demonstrate that Polycomb has a central role in transcriptional control in the newly hypomethylated germline genome as the genetic loss of Ezh2 leads to aberrant transcriptional activation, retrotransposon derepression and dramatic loss of developing female germ cells. This sex-specific effect of Ezh2 deletion is explained by the distinct landscape of repressive modifications observed in male and female germ cells. Overall, our study provides insight into the dynamic interplay between repressive chromatin modifications in the context of a developmental reprogramming system.es_ES
dc.description.sponsorshipLondon Institute of Medical Sciences (LMS)es_ES
dc.description.sponsorshipImperial College Londones_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleSex-specific chromatin remodelling safeguards transcription in germ cellses_ES
dc.typejournal articlees_ES
dc.relation.projectIDeu-repo/grantAgreement/EC/FP7/648879es_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1038/s41586-021-04208-5


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