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dc.contributor.authorGarcía Esquinas, E.
dc.contributor.authorCarballo Casla, Adrián
dc.contributor.authorOrtolá, Rosario
dc.contributor.authorSotos Prieto, Mercedes
dc.contributor.authorOlmedo Palma, Pablo 
dc.contributor.authorGil Hernández, Fernando 
dc.contributor.authorPlans Beriso, Elena
dc.contributor.authorFernández-Navarro, Pablo
dc.contributor.authorPastor-Barriuso, Roberto
dc.contributor.authorRodriguez Artalejo, Fernando
dc.date.accessioned2024-09-20T10:01:56Z
dc.date.available2024-09-20T10:01:56Z
dc.date.issued2023-11-10
dc.identifier.citationGarcía-Esquinas, E.; Carballo- Casla, A.; Ortolá, R.; Sotos-Prieto, M.; Olmedo, P.; Gil, F.; Plans-Beriso, E.; Fernández-Navarro, P.; Pastor- Barriuso, R.; Rodríguez-Artalejo, F. Blood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adults. Nutrients 2023, 15, 4750. https://doi.org/10.3390/nu15224750es_ES
dc.identifier.urihttps://hdl.handle.net/10481/94766
dc.description.abstractBackground: Seleniumis an essential trace element with an antioxidant and anti-inflammatory capacity that has been associated in experimental studies with beneficial effects on appetite control, the regulation of the gut microbiota, and control of the anabolic–catabolic balance. The main aim of the present study was to evaluate the association between circulating selenium concentrations and the risk of developing undernutrition in older adults. Methods: This was a cohort study with 1398 well-nourished community-dwelling individuals aged ≥ 65 years residing in Spain in 2017, who were followed for a mean of 2.3 years. Whole blood selenium was measured at baseline using inductively coupled plasma-mass spectrometry. Undernutrition was assessed at baseline and at follow-up, and defined as having at least one of the three GLIM phenotypic criteria (involuntary weight loss, a low body mass index, and a reduced muscle mass) and at least one of the two etiologic criteria (reduced food consumption or nutrient assimilation and inflammation/disease burden). Results: During the follow-up, 142 participants (11%) developed moderate undernutrition and 113 (8.8%) severe undernutrition. The standardized relative risks of moderate and severe undernutrition at the 75th percentile of Se levels versus the 25th were 0.90 and 0.70, respectively. In dose–response analyses, the risk of severe undernutrition decreased linearly with increasing selenium concentrations. This association was independent of protein intake or diet quality and was stronger among participants with a diagnosis of a musculoskeletal disorder. Conclusions: The results suggest that an adequate dietary selenium status is needed to prevent undernutrition in older adults. Also, this may open the door for clinical trials with selenium supplementation, at doses considered as safe, to prevent undernutrition.es_ES
dc.description.sponsorshipSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP) [ESP21PI04]es_ES
dc.description.sponsorshipCarlos III Health Institute, the Secretary of R+D+I, and the European Regional Development Fund/European Social Fund [FIS grants PI18/287 and 22/01111]es_ES
dc.description.sponsorshipMCIN/AEI/10.13039/501100011033 and the European Union “NextGenerationEU/ PRTR” [PLEC2022-009352 grant]es_ES
dc.description.sponsorshipISCIII-CDTI and the European Union “NextGenerationEU/PRTR” [PMPTA22/00107 grant]es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTrace elements es_ES
dc.subjectProtein-energy malnutritiones_ES
dc.subjectAgeinges_ES
dc.titleBlood Selenium Concentrations Are Inversely Associated with the Risk of Undernutrition in Older Adultses_ES
dc.typejournal articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/NextGenerationEU/009352es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/NextGenerationEU/00107es_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.3390/nu15224750
dc.type.hasVersionVoRes_ES


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