Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions
Metadatos
Mostrar el registro completo del ítemAutor
Vázquez Lorente, Héctor; Herrera Quintana, Lourdes María; Jiménez Sánchez, Laura; Fernández Perea, Beatriz; Plaza Díaz, JulioEditorial
MDPI
Materia
Vitamin D Antioxidant Oxidative stress
Fecha
2024-08-17Referencia bibliográfica
Vázquez-Lorente, H.; Herrera-Quintana, L.; Jiménez- Sánchez, L.; Fernández-Perea, B.; Plaza-Diaz, J. Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions. Antioxidants 2024, 13, 996. https://doi.org/10.3390/antiox13080996
Resumen
Evidence is increasing that vitamin D and CYP11A1-derived vitamin D, tachysterol, and
lumisterol metabolites play a significant antioxidant role beyond its classical functions in bone health
and calcium metabolism. Several recent studies have linked these elements to reduced oxidative
stress as well as improved immune, cardiovascular, and neurological functions as a result of chronic
kidney disease and cancer. Additionally, supplementation with this vitamin has been shown to be
one of the most cost-effective micronutrient interventions worldwide, highlighting its potential as
a therapeutic approach. The underlying mechanisms and implications of this antioxidant function
of vitamin D or CYP11A1-derived vitamin D, tachysterol, and lumisterol metabolites are not well
understood. This comprehensive and narrative review is aimed at summarizing the current evidence
regarding the molecular mechanisms implicated in this antioxidant function of vitamin D, as well as
to provide a general overview and to identify key research areas for the future, offering an extensive
perspective that can guide both researchers and clinicians in the management of diseases associated
with oxidative stress and/or insufficient vitamin D status.