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dc.contributor.authorBertolotti, Federica
dc.contributor.authorSkov Pedersen, Jan
dc.contributor.authorVan Driessche, Alexander Edgard Suzanne
dc.contributor.authorMasciocchi, Norberto
dc.contributor.authorGuagliardi, Antonietta
dc.contributor.authorDelgado López, José Manuel 
dc.date.accessioned2024-09-11T08:42:30Z
dc.date.available2024-09-11T08:42:30Z
dc.date.issued2024-08-23
dc.identifier.citationBertolotti, F. et. al. 180 (2024) 117904. [https://doi.org/10.1016/j.trac.2024.117904]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/94329
dc.description.abstractDespite the biological relevance and the unique mechanical properties of bone tissue, the pathway leading to the formation of the main mineral component – specifically, the mechanism responsible for the formation of extremely thin apatite nanoplatelets – remains unclear. In this work, the presence and evolution of an elusive octacalcium phosphate/apatite (OCP/Ap) heterostructure is identified through the combination of small- and wide-angle X-ray total scattering experiments. These experiments were performed in situ during collagen mineralization, and the structure, morphology, and epitaxy of these nanocrystalline composites are described using atomistic models. By applying the Debye Scattering Equation to our high-quality synchrotron X-ray scattering datasets, a quantitative estimate of the size and shape of the nanoplates, as well as their temporal evolution, is achieved. The transformation of this transient heterostructure is revealed through confocal Raman microscopy to occur within the intrafibrillar spaces of the collagen fibers. As mineralization progresses, these spaces gradually cluster, resulting in a ca. 60 % increase in the lateral density of the purely organic molecular bundles. In contrast, in dry collagen, the mineralization process induces a (marginal) decrease in bundles density. Despite their apparent opposite, we present an explanation that reconciles both effects.es_ES
dc.description.sponsorshipProject BioBone (Andalucía Talent Hub program, co-funded by the Spanish Junta de Andalucía and EU-FP7 within the Marie Skłodowska-Curie Actions)es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCollagen mineralizationes_ES
dc.subjectBonees_ES
dc.subjectEpitaxyes_ES
dc.titleTransient OCP-apatite epitaxy controls bone mineralization. An X-ray total scattering studyes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1016/j.trac.2024.117904
dc.type.hasVersionVoRes_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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