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dc.contributor.authorVallecillo Rivas, Marta
dc.contributor.authorFernández-Romero, Enrique
dc.contributor.authorPérez-Segura, Michelle
dc.contributor.authorToledano, Raquel
dc.contributor.authorAmar-Zetouni, Anisa
dc.contributor.authorToledano Pérez, Manuel 
dc.contributor.authorVallecillo Rivas, María Cristina
dc.date.accessioned2024-09-11T07:51:36Z
dc.date.available2024-09-11T07:51:36Z
dc.date.issued2024-08-30
dc.identifier.citationVallecillo-Rivas M, Fernández-Romero E, Pérez-Segura M, et al. Efficacy of topical application of corticosteroids in the remineralization of dental pulp tissue. A systematic review of the literature. J Dent. Published online August 30, 2024. doi:10.1016/j.jdent.2024.105333es_ES
dc.identifier.urihttps://hdl.handle.net/10481/94315
dc.descriptionThe present study was supported by Grant PID2020–114694RB-I00 funded by MCIN/AEI 10.13039/501100011033.es_ES
dc.description.abstractObjectives: The aim of this systematic review was to demonstrate the efficacy of topical application of corticosteroids in remineralization of dental pulp tissues to preserve their vitality and function. Data, sources and study selection: An electronic search was performed using MEDLINE by PubMed, EMBASE, Web of Science (WOS), and Scopus databases. The inclusion criteria were in vitro studies that employed dental pulp tissue obtained from extracted healthy permanent human teeth and were subjected to topical administration of corticosteroids and evaluated tissue remineralization by performing any mineralization assay. A total of 11 studies were selected for inclusion. PRISMA guidelines were followed, and the methodological quality and risk of bias of the included studies were evaluated using the RoBDEMAT guidelines. Also, tables were designed for data extraction, including tissue mineralization and osteogenic differentiation as primary and secondary outcomes, respectively. Conclusions: Alizarin Red S (ARS) has been able to demonstrate a possible mineralizing power of corticosteroids, applied at an adequate dose. The up-regulation of Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OSP), sialophosphoprotein (DSPP), runt-related transcription factor 2 (RUNX2), collagen type 1 alpha 1 (COL1α1) and dentin matrix protein 1 (DMP-1) induced the osteogenic/odontogenic differentiation of dental pulp stem cells (DPSCs). Clinical significance: Deep carious lesions treatment is still challenging in restorative dentistry. Some treatments have been focused on dental pulp tissue remineralization to maintain the function and vitality. After corticosteroids topical application, mineral deposition and osteogenic differentiation have been detected.es_ES
dc.description.sponsorshipMCIN/AEI 10.13039/501100011033 PID2020–114694RB-I00es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCorticosteroidses_ES
dc.subjectMesenchymal stem cellses_ES
dc.subjectMineralizationes_ES
dc.subjectOdontogenic differentiationes_ES
dc.subjectDental pulpes_ES
dc.titleEfficacy of topical application of corticosteroids in the remineralization of dental pulp tissue. A systematic review of the literaturees_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1016/j.jdent.2024.105333
dc.type.hasVersionVoRes_ES


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