Molecular Mechanisms Linking Genes and Vitamins of the Complex B Related to One-Carbon Metabolism in Breast Cancer: An In Silico Functional Database Study
Metadatos
Mostrar el registro completo del ítemAutor
Gálvez Navas, José María; Molina-Montes, Esther; Rodríguez Barranco, Miguel; Ramírez-Tortosa, M. Carmen; Gil Hernández, Ángel; Sánchez Pérez, María JoséEditorial
MDPI
Materia
one-carbon metabolism breast cancer genes
Fecha
2024-07-26Referencia bibliográfica
Gálvez Navas, J.M. et. al. Int. J. Mol. Sci. 2024, [https://doi.org/10.3390/ijms25158175]
Patrocinador
Networking Biosanitary Research Center of Epidemiology and Public Health (CIBERESP) (Instituto de Salud Carlos III)Resumen
Carcinogenesis is closely related to the expression, maintenance, and stability of DNA.
These processes are regulated by one-carbon metabolism (1CM), which involves several vitamins
of the complex B (folate, B2, B6, and B12), whereas alcohol disrupts the cycle due to the inhibition
of folate activity. The relationship between nutrients related to 1CM (all aforementioned vitamins
and alcohol) in breast cancer has been reviewed. The interplay of genes related to 1CM was also
analyzed. Single nucleotide polymorphisms located in those genes were selected by considering the
minor allele frequency in the Caucasian population and the linkage disequilibrium. These genes
were used to perform several in silico functional analyses (considering corrected p-values < 0.05 as
statistically significant) using various tools (FUMA, ShinyGO, and REVIGO) and databases such
as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and GeneOntology (GO). The results of
this study showed that intake of 1CM-related B-complex vitamins is key to preventing breast cancer
development and survival. Also, the genes involved in 1CM are overexpressed in mammary breast
tissue and participate in a wide variety of biological phenomena related to cancer. Moreover, these
genes are involved in alterations that give rise to several types of neoplasms, including breast cancer.
Thus, this study supports the role of one-carbon metabolism B-complex vitamins and genes in breast
cancer; the interaction between both should be addressed in future studies.