Association Study of Serotonin 1A Receptor Gene, Personality, and Anxiety in Women with Alcohol Use Disorder
Metadatos
Mostrar el registro completo del ítemAutor
Boroń, Agnieszka; Suchanecka, Aleksandra; Chmielowiec, Krzysztof; Chmielowiec, Jolanta; Lachowicz, Milena; Strońska-Pluta, Aleksandra; Trybek, Grzegorz; Wach, Tomasz; González Domenech, Pablo José; Grzywacz, AnnaEditorial
MDPI
Materia
alcohol use disorder serotonin receptor 1A personality
Fecha
2024-06-14Referencia bibliográfica
Boroń, A. et. al. Int. J. Mol. Sci. 2024, 25, 6563. [https://doi.org/10.3390/ijms25126563]
Resumen
Alcohol use disorder is considered a chronic and relapsing disorder affecting the central
nervous system. The serotonergic system, mainly through its influence on the mesolimbic dopaminergic
reward system, has been postulated to play a pivotal role in the underlying mechanism of
alcohol dependence. The study aims to analyse the association of the rs6295 polymorphism of the
5HTR1A gene in women with alcohol use disorder and the association of personality traits with the
development of alcohol dependence, as well as the interaction of the rs6295, personality traits, and
anxiety with alcohol dependence in women. The study group consisted of 213 female volunteers:
101 with alcohol use disorder and 112 controls. NEO Five-Factor and State-Trait Anxiety Inventories
were applied for psychometric testing. Genotyping of rs6295 was performed by real-time PCR.We
did not observe significant differences in 5HTR1A rs6295 genotypes (p = 0.2709) or allele distribution
(p = 0.4513). The AUD subjects scored higher on the anxiety trait (p < 0.0001) and anxiety state
(p < 0.0001) scales, as well as on the neuroticism (p < 0.0001) and openness (p = 0134) scales. Significantly
lower scores were obtained by the AUD subjects on the extraversion (p < 0.0001), agreeability
(p < 0.0001), and conscientiousness (p < 0.0001) scales. Additionally, we observed a significant effect
of 5HTR1A rs6295 genotype interaction and alcohol dependency, or lack thereof, on the openness
scale (p = 0.0016). In summary, this study offers a comprehensive overview of alcohol dependence
among women. It offers valuable insights into this complex topic, contributing to a more nuanced
understanding of substance use among this specific demographic. Additionally, these findings may
have implications for developing prevention and intervention strategies tailored to individual genetic
and, most importantly, personality and anxiety differences.