Development of an Emulgel for the Effective Treatment of Atopic Dermatitis: Biocompatibility and Clinical Investigation
Metadatos
Mostrar el registro completo del ítemAutor
Gómez-Farto, Almudena; Jiménez-Escobar, Ana Leticia; Pérez González, Noelia; Castán, Herminia; Clares Naveros, Beatriz; Arias Santiago, Salvador Antonio; Montero Vílchez, TrinidadEditorial
MDPI
Materia
Emulgel Atopic dermatitis Hyaluronic acid
Fecha
2024-05-27Referencia bibliográfica
Gómez Farto, A. et. al. Gels 2024, 10, 370. [https://doi.org/10.3390/gels10060370]
Patrocinador
Instituto de Investigación Biotecnológica, Farmacéutica y Medicamentos Huérfanos, S.L.; Centre for the Development of Industrial Technology (Spain); Program FEDER INTERCONECTA (ITC-20181113)Resumen
Atopic dermatitis (AD) is a common dermatological disease affecting both children and
adults. No drug-free emulgel has been developed and studied in vitro and in vivo for the treatment
of AD. The aim of this study was to develop and assess the efficacy of a topical emulgel containing
hyaluronic acid, glycerol, Calendula officinalis, Aloe vera, polyphenols and EGF for the concomitant
treatment in patients with AD aged over 14. Objective skin barrier function parameters were included,
such as transepidermal water loss (TEWL), skin temperature, pH, stratum corneum hydration,
skin elasticity and erythema. The subjective opinion of the patients was determined including
acceptability, absorption, comfort of use and tolerability, as well as the degree of improvement in
patients’ quality of life. We observed an improvement in the subjective parameters studied and
statistically significant differences in the objective parameters. Specifically, we found an improvement
in TEWL (p = 0.006), erythema (p = 0.008) and hydration (p < 0.001), parameters indicating an
improvement in the epidermal barrier. One hundred per cent of patients were satisfied with the
product. Therefore, these results suggest that the product may contribute to the treatment of AD.