A Clustering Study of Sociodemographic Data, Dietary Patterns, and Gut Microbiota in Healthy and Breast Cancer Women Participating in the MICROMA Study
Metadatos
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Ruiz-Marín, Carmen María; Álvarez Mercado, Ana Isabel; Plaza Díaz, Julio; Rodríguez Lara, Avilene; Gallart-Áragon, Tania; Sánchez-Barrón, María Teresa; de Reyes Lartategui, Saturnino; Alcaide Lucena, Miriam; Fernández, Mariana F.; Fontana Gallego, LuisEditorial
Wiley Online Library
Fecha
2024-07-01Referencia bibliográfica
Ruiz Marín, C.M. et. al. Mol. Nutr. Food Res. 2024, 2400253. [https://doi.org/10.1002/mnfr.202400253]
Patrocinador
PI-0538-2017 (Consejería de Salud, Junta de Andalucía, Spain, to L.F.); B-CTS-254-UGR18 (Programa Operativo FEDER Andalucía 2014–2020, Junta de Andalucía, Spain, to both L.F. and M.F.F.); (RPS 24665, 2021) from Consejería de Salud y Familias, Junta de Andalucía, Spain; Universidad de Granada/CBUAResumen
Scope: This work is part of the clinical study NCT03885648 registered in
ClinicalTrials.gov, aimed at studying the relationship among breast cancer,
microbiota, and exposure to environmental pollutants. As a first step, we
characterized and evaluated risk factors of the participants.
Methods and results: A case–control study was designed with breast cancer
(cases, n = 122) and healthy women (controls, n = 56) recruited in two
hospitals of Andalusia (Southern Spain). Participants answered
questionnaires of Mediterranean diet adherence and food frequency. Data
were collected from medical histories and microbiota was analyzed on stool
samples. Most cases (78.2%) were diagnosed as stages I and II. Cases had
higher age, body mass index (BMI), glucose, cholesterol, and potassium
values than controls. Cases exhibited higher adherence to the Mediterranean
diet and their food consumption was closer to that dietary pattern. A
hierarchical cluster analysis revealed that the Bacillota/Bacteroidota ratio was
the most relevant variable in women with breast cancer, which was higher in
this group compared with controls.
Conclusion: Although cases exhibited higher adherence to the Mediterranean
diet compared with controls, they presented features and microbiota
alterations typical of the metabolic syndrome, probably due to their higher
BMI and reflecting changes in their lifestyle around the time of diagnosis.